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Titolo:
Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster
Autore:
Koehler, KE; Hassold, TJ;
Indirizzi:
Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Ctr Human Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
ANNALS OF HUMAN GENETICS
, volume: 62, anno: 1998,
parte:, 6
pagine: 467 - 479
SICI:
0003-4800(199811)62:<467:HALFAS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEIOTIC CHROMOSOME SEGREGATION; KINESIN-LIKE PROTEIN; MATERNAL MEIOSIS-I; GENETIC-ANALYSIS; HUMAN OOCYTES; DISTRIBUTIVE SEGREGATION; PATERNAL NONDISJUNCTION; TRISOMY FORMATION; FEMALE MEIOSIS; DNA-BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Koehler, KE Case6Western Reserve Univ, Dept Genet, 10900 Euclid Ave, Cleveland, OH 4410 Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
K.E. Koehler e T.J. Hassold, "Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster", ANN HUM GEN, 62, 1998, pp. 467-479

Abstract

Aneuploidy is a crucial issue in human reproductive biology, accounting for both a significant proportion of miscarriages and, among liveborns, multiple congenital malformation syndromes such as Down Syndrome. Although the etiology of human aneuploidy remains poorly understood, recent studies have elucidated certain fundamental correlates of meiotic nondisjunction, such as altered recombination. These features are extraordinarily similar to those associated with chromosome misbehavior in Drosophila melanogaster females. Furthermore, these organisms also share a significant level of achiasmatechromosome nondisjunction. Here we describe in detail the processes of achiasmate chromosome segregation in Drosophila and discuss how they may be most effectively applied to our understanding of the etiology of human aneuploidy. In particular, we examine the possibility that similar "backup" mechanisms of chromosome segregation might function in mammalian meiosis, particularly mammalian females. Drawing upon observations made in flies, we also propose a new model for the segregation of achiasmate chromosomes in humans.

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Documento generato il 01/10/20 alle ore 04:20:49