Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analytical evaluation of a third generation TSH assay - Assessment of thyroxine suppression in differentiated thyroid carcinoma
Autore:
Charrie, A; Mesnard, X; Tourniaire, J;
Indirizzi:
Hop Antiquaille, Nucl Med Lab, F-69321 Lyon 05, France Hop Antiquaille Lyon France 05 le, Nucl Med Lab, F-69321 Lyon 05, France Hop Antiquaille, Clin Endocrinol, F-69321 Lyon, France Hop Antiquaille Lyon France F-69321 lin Endocrinol, F-69321 Lyon, France
Titolo Testata:
ANNALES D ENDOCRINOLOGIE
fascicolo: 1, volume: 60, anno: 1999,
pagine: 40 - 44
SICI:
0003-4266(199903)60:1<40:AEOATG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
FRE
Soggetto:
SENSITIVE THYROTROPIN ASSAYS; PERFORMANCE GOALS; HORMONE; THERAPY; RESPONSES; DISEASE;
Keywords:
third generation TSH; functional sensitivity; thyroid cancer; suppressive thyroid; therapy TRH test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A. Charrie et al., "Analytical evaluation of a third generation TSH assay - Assessment of thyroxine suppression in differentiated thyroid carcinoma", ANN ENDOCR, 60(1), 1999, pp. 40-44

Abstract

Intravenous TRH (200 mu g Protirtline*) injection was performed in 137 patients who had undergone thyroidectomy for differentiated thyroid carcinoma and treated by a suppressive thyroid therapy. Serum thyroid stimulating hormone (TSH) was measured before and 30 minutes after the injection. 143 tests were performed. The TSH method used was a chemiluminometric assay (ChironDiagnostics). We study the analytical characteristics of the method. The limit of detection was 0.003 mUI/l. Interassay precision showed a functionalsensitivity of 0.015 m UI/l with 20 % interassay CV in agreement with the third generation criterion. There was a good correlation between TSH values at T0 and T30 minutes. In 143 rests, 40 (28 %) showed a basal TSH value less than 0.003 mUI/l; Delta TSH (TSH at T30 - TSH at T0) was less than 0.015 mUI/l in about 68 % of thecases and less than 0.031 mUI/l for the others. In 20 % of the tests (29) TSH T0 were between 0.003 and 0.015 mUI/l and Delta TSH less than 0.204 mUI/l. Finally the 74 remaining tests with a basal TSH value higher than the functional sensitivity of the method showed Delta TSN less than 0.4 mUI/l ifthe TSH T0 was less than 0.05 mUI/l. The Delta TSH remained less than 0.6 mUI/l if the TSH T0 was less than 0.1 mUI/l. Inversely, if TSH T0 was higher than 0.1 mUI/l Delta TSH could be higher than 1.0 mUI/l. Third generation TSH assay allows us to abandon TRH test for the follow-upof thyroidectomized patients with suppressive thyroid hormonotherapy in sofar as TSH assay is well established. We conclude that a basal TSH less than the functional sensitivity (0.015 mUI/l) can predict a TSH response to TRH stimulation test less than 0.2 mUI/l.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:31:15