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Titolo:
The central melanocortin system and its role in energy homeostasis.
Autore:
Cone, RD;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA
Titolo Testata:
ANNALES D ENDOCRINOLOGIE
fascicolo: 1, volume: 60, anno: 1999,
pagine: 3 - 9
SICI:
0003-4266(199903)60:1<3:TCMSAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
FRE
Soggetto:
PROOPIOMELANOCORTIN MESSENGER-RNA; AGOUTI OBESITY SYNDROME; EARLY-ONSET OBESITY; NEUROPEPTIDE-Y; FRAMESHIFT MUTATION; GENE-EXPRESSION; ARCUATE NUCLEUS; FOOD-INTAKE; OB/OB MICE; LEPTIN;
Keywords:
obesity; energy homeostasis; melanocortins; melanocortin-4 receptor (MC4-R);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Cone, RD Oregon Hlth Sci Univ, Vollum Inst, L474, Portland, OR 97201 USA Oregon Hlth Sci Univ L474 Portland OR USA 97201 and, OR 97201 USA
Citazione:
R.D. Cone, "The central melanocortin system and its role in energy homeostasis.", ANN ENDOCR, 60(1), 1999, pp. 3-9

Abstract

Obesity is an important health concern, and the central melanocortin system is likely to play an important role in both normal regulation of energy homeostasis as well as genetic predisposition to obesity. Three different mouse models of obesity have been created by virtue of mutations which alter the function of the melanocortin system, and a rare form of human obesity has been characterized in two families with mutations in the proopiomelanocortin gene [26]. More recently published works suggests an association between common childhood obesity and dominant inheritance of a single null allele of the melanocortin-4 receptor [44,49]. Experimental work in the rodent suggests that the central melanocortin system may be a fundamental componentof the adipostat, the mechanism by which constant energy stores are maintained. This hypothesis is the subject of this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:36:32