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Titolo:
Preliminary evidence of low cortical GABA levels in localized H-1-MR spectra of alcohol-dependent and hepatic encephalopathy patients
Autore:
Behar, KL; Rothman, DL; Petersen, KF; Hooten, M; Delaney, R; Petroff, OAC; Shulman, GI; Navarro, V; Petrakis, IL; Charney, DS; Krystal, JH;
Indirizzi:
Yale Univ, MRC, Dept Neurol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 RC, Dept Neurol, New Haven, CT 06520 USA Yale Univ, Dept Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 iv, Dept Radiol, New Haven, CT 06520 USA Yale Univ, Dept Internal Med, New Haven, CT 06520 USA Yale Univ New HavenCT USA 06520 pt Internal Med, New Haven, CT 06520 USA Yale Univ, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA VA Connecticut Healthcare Syst, W Haven, CT USA VA Connecticut Healthcare Syst W Haven CT USA care Syst, W Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 6, volume: 156, anno: 1999,
pagine: 952 - 954
SICI:
0002-953X(199906)156:6<952:PEOLCG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Behar, KL Yale Univ, MRC, Dept Neurol, POB 208043, New Haven, CT 06520 USAYale Univ POB 208043 New Haven CT USA 06520 Haven, CT 06520 USA
Citazione:
K.L. Behar et al., "Preliminary evidence of low cortical GABA levels in localized H-1-MR spectra of alcohol-dependent and hepatic encephalopathy patients", AM J PSYCHI, 156(6), 1999, pp. 952-954

Abstract

Objective: The aim of the study was to compare levels of neuroactive aminoacids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy. Method: Metabolite levels were measured in the occipital cortex by using spatially localized H-1-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects. Results: The combined level of gamma-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects. Conclusions: The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:08:06