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Titolo:
Gender and age influences on human brain mu-opioid receptor binding measured by PET
Autore:
Zubieta, JK; Dannals, RF; Frost, JJ;
Indirizzi:
Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Neurosci, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ci, Baltimore, MD 21287 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 6, volume: 156, anno: 1999,
pagine: 842 - 848
SICI:
0002-953X(199906)156:6<842:GAAIOH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; COMPUTED-TOMOGRAPHY; ALZHEIMERS-DISEASE; SUICIDE VICTIMS; SEX-DIFFERENCES; METABOLISM; WOMEN; ESTROGEN; FEMALES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Frost, JJ Johnsaltimore,Med Inst, Dept Radiol, Div Nucl Med, B1-130,600 N Wolfe St, B Johns Hopkins Med Inst B1-130,600 N Wolfe St Baltimore MD USA 21287
Citazione:
J.K. Zubieta et al., "Gender and age influences on human brain mu-opioid receptor binding measured by PET", AM J PSYCHI, 156(6), 1999, pp. 842-848

Abstract

Objective: Both age and gender are being increasingly recognized as important factors influencing CNS structure and function. However, there are relatively few data on actual neurochemical differences between the sexes in human subjects or on their interaction with age. One of the central neurotransmitter systems for which sex differences have been suggested by animal models and clinical human data is the opioid. In this study the authors examined age- and gender-associated variations in mu-opioid receptor binding withpositron emission tomography (PET). Method: Healthy human subjects were studied with PET and the radiotracer [C-11]carfentanil, a selective mu-opioidagonist. Two separate subject groups were examined: one group of 24 men and 12 women was studied in a retrospective analysis of data, and a second group of 12 men and 18 women was recruited prospectively and studied with a higher-resolution scanner. Results: Mu-opioid receptor binding potential (B-max/K-d) was found to increase with age in neocortical areas and the putamen. Sex differences, with higher mu-opioid binding in women, were observed in a number of cortical and subcortical areas. Gender-by-age interactions were observed in the thalamus and the amygdala; in vivo mu-opioid binding declined in postmenopausal women to levels below those of men. Conclusions: These data imply that both age and gender are important variables to considerin the interpretation of investigations of human function in which the opioid system plays a role. Also, women's reproductive status (reproductive age versus postmenopausal) may influence the function of CNS opioid systems.

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Documento generato il 09/07/20 alle ore 16:43:42