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Titolo:
Amiloride-sensitive sodium signals and salt appetite: multiple gustatory pathways
Autore:
Roitman, MF; Bernstein, IL;
Indirizzi:
Univ Washington, Program Neurobiol & Behav, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 obiol & Behav, Seattle, WA 98195 USA Univ Washington, Dept Psychol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Psychol, Seattle, WA 98195 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 45, anno: 1999,
pagine: R1732 - R1738
SICI:
0363-6119(199906)45:6<R1732:ASSASA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREATER SUPERFICIAL PETROSAL; CHORDA TYMPANI; TASTE RESPONSES; RATS; NACL; INHIBITION; NERVE; SPECIFICITY; FISCHER-344; TRANSECTION;
Keywords:
sodium appetite; chorda tympani; taste; sham drinking; greater superficial petrosal nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Roitman, MF UnivSAashington, Program Neurobiol & Behav, Box 351525, Seattle, WA 98195 U Univ Washington Box 351525 Seattle WA USA 98195 le, WA 98195 U
Citazione:
M.F. Roitman e I.L. Bernstein, "Amiloride-sensitive sodium signals and salt appetite: multiple gustatory pathways", AM J P-REG, 45(6), 1999, pp. R1732-R1738

Abstract

In the rat, the ionic specificity of Na+ appetite is thought to rely on amiloride-sensitive Na+ signals conveyed by the chorda tympani (CT) nerve. Weevaluated whether robust Na+ appetite relies exclusively on CT-mediated amiloride-sensitive Na+ signals. Amiloride dramatically reduced sham drinkingof NaCl (41.9 +/- 9.0 vs. 6.9 +/- 3.7 ml, 0.1 M NaCl without vs. with 100 mu M amiloride), which resulted in intake that was not different from intake of a non-Na+ salt solution (8.8 +/- 2.3 ml, 0.15 M KCl). In addition, intake of 0.1 M NaCl in CT-transected (CTX) rats was reduced (35.8 +/- 13.3 vs. 8.67 +/- 3.4 ml, sham-operated vs. CTX rats), but the addition of amiloride (100 mu M) further reduced intake in CTX rats (0.5 +/- 0.29 ml). These data support the idea that amiloride-sensitive Na+ channels are the criticalgustatory substrate for Na+ identification during Na+ appetite in the rat. However, the data indicate that these amiloride-sensitive signals are not conveyed exclusively by the CT nerve but by an additional afferent pathway.

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Documento generato il 02/07/20 alle ore 22:11:56