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Titolo:
Sixth World Congress of Psychiatric Genetics X Chromosome Workshop
Autore:
Paterson, AD; DeLisi, L; Faraone, SV; Gejman, PV; Goossens, D; Hovatta, I; Kaufmann, CA; Klauck, SM; Kunugi, H; Levinson, DF; Mors, O; Norton, N; Smalley, SL;
Indirizzi:
UnivtToronto, Dept Psychiat, Ctr Addict & Mental Hlth, Clarke Div,Neurogene Univ Toronto Toronto ON Canada M5T 1R8 Mental Hlth, Clarke Div,Neurogene
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 3, volume: 88, anno: 1999,
pagine: 279 - 286
SICI:
0148-7299(19990618)88:3<279:SWCOPG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE SEARCH; SCHIZOPHRENIA SUSCEPTIBILITY GENES; BIPOLAR AFFECTIVE-DISORDER; MILLENNIUM-CONSORTIUM; LINKAGE ANALYSIS; COMPLEX TRAITS; NO EVIDENCE; PROGRESS; LOCI; SCAN;
Keywords:
X chromosome; linkage; bipolar affective disorder; schizophrenia; attention deficit hyperactivity disorder; autism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Paterson, AD UnivtToronto, Dept Psychiat, Ctr Addict & Mental Hlth, ClarkeDiv,Neurogene Univ Toronto 250 Coll St Toronto ON Canada M5T 1R8 ,Neurogene
Citazione:
A.D. Paterson et al., "Sixth World Congress of Psychiatric Genetics X Chromosome Workshop", AM J MED G, 88(3), 1999, pp. 279-286

Abstract

At the X chromosome workshop of the Sixth World Congress on Psychiatric Genetics, new data regarding psychiatric phenotypes and the X chromosome werepresented, In the last year a number of groups have published linkage results for the X chromosome in schizophrenia, which provide no significant evidence for linkage. Presentations by groups from Cardiff, Oxford, State University of New York (SUNY), and Finland provide weak nonsignificant evidencefor linkage of markers on the Xp11.4-p11.3, Xq21, and Xq26 with schizophrenia. However, the presence of a male-specific transmission ratio distorter (DMS1) that maps to Xp11.4-21.2 [Naumova et al,, 1998: Am, J, Hum, Genet, 62:1493-1499] makes the interpretation of linkage findings in brother-brother pairs difficult in this region. Regarding bipolar affective disorder, little new data were reported, but previous reports provide evidence for linkage to Xq25-q26, Summary tables of linkage results for schizophrenia and bipolar disorder can be obtained from http://www.camh.net/ research/x-chromosome/. No linkage or transmission disequilibrium of polymorphisms of MAOA andMAOB in attention deficit hyperactivity disorder was seen, Negative results for transmission disequilibrium of polymorphisms of HTR2C and MAOA with autism were provided from German and Austrian families. Am, J. Med. Genet. (Neuropsychiatr. Genet,) 88:279-286, 1999, (C) 1999 Wiley-Liss, Inc.

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Documento generato il 31/03/20 alle ore 19:43:19