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Titolo:
ASSESSMENT OF CEREBROVASCULAR REACTIVITY BY DYNAMIC SUSCEPTIBILITY CONTRAST-ENHANCED MR-IMAGING
Autore:
NIGHOGHOSSIAN N; BERTHEZENE Y; MEYER R; CINOTTI L; ADELEINE P; PHILIPPON B; FROMENT JC; TROUILLAS P;
Indirizzi:
HOP NEUROL,SERV NEUROL PR PAUL TROUILLAS,URGENCES NEUROVASC,DEPT NEUROL CEREBROVASC DIS F-69003 LYON FRANCE HOP NEUROL,ATAXIA RES CTR F-69003 LYON FRANCE NEUROL HOSP,DEPT RADIOL LYON FRANCE NEUROL HOSP,DEPT NUCL MED LYON FRANCE UFR ALEXIS CARREL,LAB INFORMAT MED LYON FRANCE
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 149, anno: 1997,
pagine: 171 - 176
SICI:
0022-510X(1997)149:2<171:AOCRBD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; CAROTID-ARTERY OCCLUSION; IC BYPASS-SURGERY; TRANSCRANIAL DOPPLER; ACETAZOLAMIDE CHALLENGE; VELOCITY-MEASUREMENTS; STROKE RISK; RESERVE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
N. Nighoghossian et al., "ASSESSMENT OF CEREBROVASCULAR REACTIVITY BY DYNAMIC SUSCEPTIBILITY CONTRAST-ENHANCED MR-IMAGING", Journal of the neurological sciences, 149(2), 1997, pp. 171-176

Abstract

In patients with cerebrovascular disease the acetazolamide (ACZ) testis performed to evaluate the decrease in cerebral perfusion pressure (CPP) through the investigation of the vasomotor reactivity (VMR). This latter is currently assessed with ACZ with several methods. Recently, magnetic resonance imaging (MRI) techniques have been developed thatare sensitive to stimulus-induced changes in ii blood flow. Dynamic susceptibility contrast material-enhanced gradient-echo MRI techniques (DSC-MRI) might be an attractive tool to assess VMR. We aimed to test the ability of DSC-MRI in the assessment of VMR. Relative hemodynamic parameters rCBV, MTT, and rCBF were evaluated at baseline after the first injection of gadopentetate dimeglumine and 10 min after the intravenous administration of ACZ (1 g) with a second bolus of contrast agent. Assessment of hemodynamic parameters was performed over the whole hemisphere and also within regions of interest. The significances of the mean differences, before and after ACZ, were assessed with repeated-measures ANOVA with two within factors: laterality (right-left) and ACZ. DSC-MRI with ACZ test was performed in ten healthy controls (aged 51.4+/-16.2 years). The cerebral hemispheric ratio for the three parameters (cerebral blood volume (CBV), mean transit time (MTT), and cerebral blood flow (CBF)) ranged between 1.01 and 1.03. The mean gray matter-to-white matter ratio for CBV, CBF and MTT were 2.44, 2.41 and 1.05,respectively. As the laterality effect was not significant, left and right hemispheric values were averaged. A significant increase of all hemodynamic parameters was observed after ACZ (P<0.01-0.001). The samechanges for CBV, CBF and MTT were observed after ACZ according to theregions of interest (P<0.006-0.015). DSC-MRI is a non-invasive methodwhich enables the assessment of VMR. This technique may be added to any conventional MRI in order to detect a hemodynamic impact of an ICA stenosis. Therefore, it might be useful in determining the appropriatemanagement when the indication for surgical versus medical therapy isin question. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:30:49