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Titolo:
Microsatellites provide evidence for Y chromosome diversity among the founders of the New World
Autore:
Ruiz-Linares, A; Ortiz-Barrientos, D; Figueroa, M; Mesa, N; Munera, JG; Bedoya, G; Velez, ID; Garcia, LF; Perez-Lezaun, A; Bertranpetit, J; Feldman, MW; Goldstein, DB;
Indirizzi:
Univ Antioquia, Fac Med, Medellin, Colombia Univ Antioquia Medellin Colombia Antioquia, Fac Med, Medellin, Colombia Univ Antioquia, Dept Antropol, Medellin, Colombia Univ Antioquia Medellin Colombia uia, Dept Antropol, Medellin, Colombia Northwick Pk Hosp, Imperial Coll, Sch Med, Dept Community Genet, Harrow HA1 Northwick Pk Hosp Harrow Middx England HA1 3UJ ommunity Genet, Harrow HA1 Univ Barcelona, Fac Biol, Unitat Antropol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ntropol, E-08028 Barcelona, Spain Stanford Univ, Dept Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iv, Dept Biol, Stanford, CA 94305 USA Univ Oxford, Dept Zool, Oxford OX1 3PS, England Univ Oxford Oxford England OX1 3PS d, Dept Zool, Oxford OX1 3PS, England Univ London Univ Coll, Dept Biol, London NW1 2HE, England Univ London UnivColl London England NW1 2HE ol, London NW1 2HE, England
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 11, volume: 96, anno: 1999,
pagine: 6312 - 6317
SICI:
0027-8424(19990525)96:11<6312:MPEFYC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIVE-AMERICAN; MTDNA; POLYMORPHISMS; HAPLOTYPES; FREQUENCIES; POPULATIONS; AMERINDIANS; TRANSITION; DISTANCES; MUTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ruiz-Linares, A Univ Antioquia, Fac Med, Apartado Aereo 1226, Medellin, Colombia Univ Antioquia Apartado Aereo 1226 Medellin Colombia bia
Citazione:
A. Ruiz-Linares et al., "Microsatellites provide evidence for Y chromosome diversity among the founders of the New World", P NAS US, 96(11), 1999, pp. 6312-6317

Abstract

Recently, Y chromosome markers have begun to be used to study Native American origins, Available data have been interpreted as indicating that the colonizers of the Ne,New World carried a single founder haplotype, However, these early studies have been based on a few mostly complex polymorphisms ofinsufficient resolution to determine whether observed diversity stems fromadmixture or diversity among the colonizers. Because the interpretation ofY chromosomal variation in the New World depends on founding diversity, itis important to develop marker systems with finer resolution, Here we evaluate the hypothesis of a single-founder Y haplotype for Amerinds by using 11 Y-specific markers in five Colombian Amerind populations, Two of these markers (DYS271, DYS287) are reliable indicators of admixture and detected three non-Amerind chromosomes in our sample. Two other markers (DYS199, M19) are single-nucleotide polymorphisms mostly restricted to Native Americans. The relatedness of chromosomes defined by these two markers was evaluated by constructing haplotypes with seven microsatellite loci (DYS388 to 394), The microsatellite backgrounds found on the two haplogroups defined by marker DYS199 demonstrate the existence of at least two Amerind founder haplotypes, one of them (carrying allele DYS199 T) largely restricted to Native Americans. The estimated age and distribution of these haplogroups places themamong the founders of the New World.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 16:09:23