Catalogo Articoli (Spogli Riviste)

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Titolo:
Expression by endothelial precursors of a new family of receptors sharing similarities with CXC chemokine receptors.
Autore:
Devic, E; Rizzoti, K; Bodin, S; Paquereau, L; Knibiehler, B; Audigier, Y;
Indirizzi:
CHU Rangueil, INSERM, U397, F-31403 Toulouse 4, France CHU Rangueil Toulouse France 4 INSERM, U397, F-31403 Toulouse 4, France
Titolo Testata:
PATHOLOGIE BIOLOGIE
fascicolo: 4, volume: 47, anno: 1999,
pagine: 330 - 338
SICI:
0369-8114(199904)47:4<330:EBEPOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
FRE
Soggetto:
TYROSINE KINASE; GROWTH-FACTOR; TIE2 RECEPTOR; GENE; VASCULOGENESIS; CLONING; LIGAND; CELLS; ANGIOPOIETIN-1; ANGIOGENESIS;
Keywords:
G protein-coupled receptors; chemokines; endothelium; embryogenesis; Xenope; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Devic, E CHUFranceeil, INSERM, U397, Bat L3,1 Ave Jean Pouhles, F-31403 Toulouse 4, CHU Rangueil Bat L3,1 Ave Jean Pouhles Toulouse France 4 ouse 4,
Citazione:
E. Devic et al., "Expression by endothelial precursors of a new family of receptors sharing similarities with CXC chemokine receptors.", PATH BIOL, 47(4), 1999, pp. 330-338

Abstract

Characterization of a new family of G protein-coupled receptors is reported. Expression of these receptors is associated with endothelial lineage. Cloning of the Xenope X-msr receptor allowed to show that embryonic expression of this receptor occurred in the heart and developing primary blood vessels. Furthermore, within these cardiovascular structures, expression was restricted to the endothelial layer. Because structural similarities with the human orphan receptor h-APJ were found the msr/apj receptor was cloned in mice. This showed that embryonic expression of this receptor was also confined to endothelial precursors. Thus, this receptor is the orthological equivalent in mice to the amphibian receptor X-msr. Molecular phylogenesis studies showed that the X-msr, msr/apj, and h-APJ receptors shared considerable homology with two CXC chemokine receptors, namely LCR1, whose name was recently changed to CXCR4, and RDC1, which is structurally similar to the CXCR2receptor. The human h-APJ receptor is a co-receptor for entry of the HIV into T cells, a property associated only with CXC chemokine receptors in thelymphocyte population. These data suggest that this new signaling system may participate in endothelial precursor migration during developmental angiogenesis and in endothelial cell migration and proliferation during neoangiogenesis in adults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:24:04