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Titolo:
Involvement of nitric oxide in aminoglycoside vestibulotoxicity in guinea pigs
Autore:
Nakagawa, T; Yamane, H; Takayama, M; Sunami, K; Nakai, Y;
Indirizzi:
Yodagawa Christian Hosp, Dept Otorhinolaryngol, Osaka 5330032, Japan Yodagawa Christian Hosp Osaka Japan 5330032 ryngol, Osaka 5330032, Japan Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Osaka 5450051, Japan Osaka City Univ Osaka Japan 5450051 orhinolaryngol, Osaka 5450051, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 267, anno: 1999,
pagine: 57 - 60
SICI:
0304-3940(19990521)267:1<57:IONOIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; APOPTOSIS; SUPEROXIDE; MECHANISMS; SYSTEM;
Keywords:
nitric oxide; nicotinamide adenine dinucleotide phosphate-diapholase; vestibular hair cell; apoptosis; aminoglycosides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, T Yodagawa Christian Hosp, Dept Otorhinolaryngol, Osaka 5330032,Japan Yodagawa Christian Hosp Osaka Japan 5330032 a 5330032, Japan
Citazione:
T. Nakagawa et al., "Involvement of nitric oxide in aminoglycoside vestibulotoxicity in guinea pigs", NEUROSCI L, 267(1), 1999, pp. 57-60

Abstract

Involvement of nitric oxide (NO) has been reported in physiological and pathological conditions in the inner ear. Recently, the presence of nitric oxide synthase (NOS) was demonstrated in the vestibular epithelium. In this study we used nicotinamide adenine dinucleotide phosphate-diapholase staining to monitor NOS activity during degeneration of guinea pig vestibular epithelia affected by streptomycin. Increased NOS activity was observed in affected epithelia in a dose- and time-dependent manner and a NOS inhibitor could protect hair cells from apoptosis. Additionally, cycloheximide significantly reduced NOS activity and the occurrence of apoptosis. These findings suggest that NO is involved in the degenerative process of vestibular epithelia caused by aminoglycosides. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:37:44