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Titolo:
Anti-analgesia and reduced antinociception from supraspinally administeredbeta-endorphin in stressed rats: dependence on spinal cholecystokinin via cholecystokinin B receptors
Autore:
Hawranko, AA; Serafini, M; Smith, DJ;
Indirizzi:
Wantown,ia Univ, Robert C Byrd Hlth Sci Ctr, Dept Pharmacol & Toxicol, Morg W Virginia Univ Morgantown WV USA 26506 r, Dept Pharmacol & Toxicol, Morg
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 267, anno: 1999,
pagine: 101 - 104
SICI:
0304-3940(19990528)267:2<101:AARAFS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS RAPHE MAGNUS; PERIAQUEDUCTAL GRAY; MORPHINE ANALGESIA; ANTAGONIST; CCK; NEUROTENSIN; NEURONS; CORD; HYPERALGESIA; L-365,260;
Keywords:
beta-endorphin; pronociception; antinociception; anti-analgesia; cholecystokinin; L-365,260; L-364,718; pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, DJ Wantown,ia Univ, Robert C Byrd Hlth Sci Ctr, Dept Pharmacol & Toxicol, Morg W Virginia Univ Morgantown WV USA 26506 armacol & Toxicol, Morg
Citazione:
A.A. Hawranko et al., "Anti-analgesia and reduced antinociception from supraspinally administeredbeta-endorphin in stressed rats: dependence on spinal cholecystokinin via cholecystokinin B receptors", NEUROSCI L, 267(2), 1999, pp. 101-104

Abstract

Rats exposed to the stress of repeated exposure to a noxious heat source (52.5 degrees C, hot plate) exhibit stress-induced analgesia, but reduced antinociception (detected using the tail-flick test) to the administration ofbeta-endorphin into the periaqueductal gray region of the brain. This is accompanied by an anti-analgesic response (reduction in the stress-induced increase of tail flick latency) to doses of beta-endorphin (0.03 nmol) lowerthan those usually associated with antinociception. These alterations are prevented and antinociceptive potency is maintained when rats are treated with cholecystokinin (CCK) antagonists intrathecally. The potency of L-365,260 and L-364,718, selective CCKB and CCKA receptor antagonists, respectively, correlated with their apparent affinities for CCKB receptors, suggestingthat the altered sensitivity to beta-endorphin is mediated via CCKB receptors. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:21:36