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Titolo:
Overexpression of human copper zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (ecstasy)
Autore:
Jayanthi, S; Ladenheim, B; Andrews, AM; Cadet, JL;
Indirizzi:
NIDA, Mol Neuropsychiat Sect, NIH, Bethesda, MD 20892 USA NIDA Bethesda MD USA 20892 europsychiat Sect, NIH, Bethesda, MD 20892 USA NIDA, Clin Sci Lab, NIH, Bethesda, MD 20892 USA NIDA Bethesda MD USA 20892 IDA, Clin Sci Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 91, anno: 1999,
pagine: 1379 - 1387
SICI:
0306-4522(1999)91:4<1379:OOHCZS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MDMA ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONIN NEUROTOXICITY; LIPID-PEROXIDATION; FREE-RADICALS; RAT-BRAIN; NEURONS; ACID; NEURODEGENERATION; DOPAMINE;
Keywords:
MDMA; superoxide dismutase; transgenic mice; antioxidant enzymes; biogenic amines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Cadet, JL NIDA, Mol Neuropsychiat Sect, NIH, Bethesda, MD 20892 USA NIDA Bethesda MD USA 20892 at Sect, NIH, Bethesda, MD 20892 USA
Citazione:
S. Jayanthi et al., "Overexpression of human copper zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (ecstasy)", NEUROSCIENC, 91(4), 1999, pp. 1379-1387

Abstract

Administration of 3,4-methylenedioxymethamphetamine (4 x 20 mg/kg) to non-transgenic CD-I mice caused marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and 5-hydroxytryptamine in the caudate-putamen. There were nosignificant changes in serotonergic markers in the hippocampus and frontalcortex. Homozygous and heterozygous copper/zinc superoxide dismutase transgenic mice show partial protection against the toxic effects of 3,4-methylenedioxymethamphetamine on striatal dopaminergic markers. In addition, 3,4-methylenedioxymethamphetamine injections caused marked decreases in copper/zinc superoxide dismutase activity in the frontal cortex, caudate-putamen and hippocampus of wild-type mice. Moreover, there were concomitant 3,4-methylenedioxymethamphetamine-induced decreases in catalase activity in the caudate-putamen and hippocampus, decreases in glutathione peroxidase activity in the frontal cortex as well as increases in lipid peroxidation in the frontal cortex: caudate-putamen, and hippocampus of wild-type mice. In contrast, administration of 3,4-methylenedioxymethamphetamine to homozygous superoxide dismutase transgenic mice caused no significant changes in antioxidant enzyme activities nor in lipid peroxidation. These results provide further substantiation of a role for oxygen-based radicals in 3,4-methylenedioxymethamphetamine-induced neurotoxicity. The present data also suggest that free radicals generated during 3,4-methylenedioxymethamphetamine administration may perturb antioxidant enzymes. Consequently. there might be further overproduction of free radicals with associated peroxidative damage to cell membranes and associated terminal degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:55:33