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Titolo:
Temporal modulation of GABA(A) receptor subunit gene expression in developing monkey cerebral cortex
Autore:
Huntsman, MM; Munoz, A; Jones, EG;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 91, anno: 1999,
pagine: 1223 - 1245
SICI:
0306-4522(1999)91:4<1223:TMOGRS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GENICULATE-NUCLEUS; SENSORY-MOTOR CORTEX; CAT VISUAL-CORTEX; ACTIVITY-DEPENDENT REGULATION; CALLOSAL PROJECTION NEURONS; OCULAR DOMINANCE COLUMNS; GAMMA-AMINOBUTYRIC ACID; MOUSE BARREL CORTEX; FETAL RHESUS-MONKEY; MESSENGER-RNAS;
Keywords:
area 17; sensorimotor cortex; in situ hybridization; afferent innervation; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, EG Univ Calif Davis, Ctr Neurosci, 1544 Newton Court, Davis, CA 95616 USA Univ Calif Davis 1544 Newton Court Davis CA USA 95616 95616 USA
Citazione:
M.M. Huntsman et al., "Temporal modulation of GABA(A) receptor subunit gene expression in developing monkey cerebral cortex", NEUROSCIENC, 91(4), 1999, pp. 1223-1245

Abstract

In situ hybridization histochemistry was used to examine the expression of10 GABA(A) receptor messenger RNAs corresponding to the alpha(1)-alpha(5),beta(1)-beta(3), gamma(1) and gamma(2) subunits in primary somatosensory and visual areas of macaque monkey cerebral cortex from embryonic day (E) 125 to postnatal day (P) 125. Results were compared with expression patterns in adults. In the sensorimotor cortex at E125, overall levels of all subunit transcripts were low. At E137, there was a major lamina-specific increasein all subunit messenger RNAs except gamma(1). For alpha(1), alpha(2), alpha(4), beta(2), beta(3) and gamma(1) subunit transcripts, this increase washighest in areas 3a and 3b, particularly in layers III/IV and VI. Postnatally, there were significant decreases in all transcripts. alpha(1), alpha(5), beta(2) and gamma(2) subunit transcripts, while still at significantly lower levels than at E137, remained expressed at levels higher than other transcripts. Unlike in rodents, there was no obvious "switch" in the major subunits expressed in fetal and adult cortex, alpha(1), alpha(5), beta(2) andgamma(2) remaining highest throughout. In area 17, the most prominently expressed subunits at earliest ages were alpha(2), alpha(5), beta(1), beta(2), beta(3) and gamma(2), especially in layers II/III and VI. At E150, expression for alpha(2), alpha(3), beta(1) and beta(3) subunit transcripts in these layers decreased, but levels for alpha(1), alpha(4), alpha(5), beta(2), gamma(1) and gamma(2) transcripts increased, particularly within layer IV. The increase at E150 was particularly marked for alpha(5) transcripts, which were expressed at levels more than four times those of other transcripts.alpha(1), beta(2) and gamma(2) remain highest into aduthood. Fetal area 17displayed lamina-specific patterns of expression not found in adult animals. In particular, alpha(3) messenger RNAs were present in layer IVA and gamma(1) transcripts were present in layer IVC at E150, despite a lack of expression in these layers in the adult. These data demonstrate increased expression of GABA(A) receptors during the period of establishment of thalamocortical and intracortical connections,and a temporal regulation that may be associated with the period of developmental plasticity. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 01/04/20 alle ore 22:34:54