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Titolo:
Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites
Autore:
Mamiya, T; Noda, Y; Nishi, M; Takeshima, H; Nabeshima, T;
Indirizzi:
Nagoyaoya,v, Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, Nag Nagoya Univ Nagoya Aichi Japan 4668560 rmacol & Hosp Pharm, Showa Ku, Nag Univ Tokyo, Fac Med, Dept Pharmacol, Bunkyo Ku, Tokyo 1138565, Japan Univ Tokyo Tokyo Japan 1138565 harmacol, Bunkyo Ku, Tokyo 1138565, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1171 - 1175
SICI:
0959-4965(19990426)10:6<1171:NSPARI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION BEHAVIOR; DIZOCILPINE-INDUCED IMPAIRMENT; HIPPOCAMPAL CA1 REGION; RECEPTOR-KNOCKOUT MICE; OPIOID RECEPTOR; ORPHANIN-FQ; NITRIC-OXIDE; PROTEIN; LTP; FQ/NOCICEPTIN;
Keywords:
C57 mice; learning and memory; naloxone benzoylhydrazone (NalBzoH); nociceptin; nociceptin receptor knockout mice; passive avoidance task;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T NagoyaTsurumaSch Med, Dept Neuropsychopharmacol & Hosp Pharm,Showa Ku, 65 Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668560 Ku, 65
Citazione:
T. Mamiya et al., "Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites", NEUROREPORT, 10(6), 1999, pp. 1171-1175

Abstract

WE investigated the role of nociceptin system in learning and memory in mice. The deficiency of nociceptin receptors and nociceptin itself did not affect the alternation behavior in the Y-maze test. In the passive avoidance test, the step-through latencies of nociceptin receptor knockout mice were longer than those of wild-type mice. Nociceptin shortened the step-through latency in wild-type mice. This impairment on passive avoidance task was reversed by naloxone benzoylhydrazone (NalBzoH), indicating that the amnesic effects of nociceptin may be mediated through the NalBzoH: recognition sites. These suggest that nociceptin system plays an important role in the memory retention of passive avoidance task, and NalBzoH-recognized sites are involved in nociceptin-induced impairment of the memory retention. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:17:15