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Titolo:
The phenotypic characteristics of heterozygous reeler mouse
Autore:
Tueting, P; Costa, E; Dwivedi, Y; Guidotti, A; Impagnatiello, F; Manev, R; Pesold, C;
Indirizzi:
UnivAIllinois, Coll Med, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 US Univ Illinois Chicago IL USA 60612 t, Dept Psychiat, Chicago, IL 60612 US
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1329 - 1334
SICI:
0959-4965(19990426)10:6<1329:TPCOHR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; SCHIZOPHRENIA; NEURONS; CORTEX; BRAIN; MICE; RATS;
Keywords:
GAD; NADPH-d neurons; neuronal migration; PPI; prepulse inhibition; psychosis; reelin; Reln; schizophrenia; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tueting, P Univicago,ois, Coll Med, Inst Psychiat, Dept Psychiat, 1601 W Taylor St, Ch Univ Illinois 1601 W Taylor St Chicago IL USA 60612 ylor St, Ch
Citazione:
P. Tueting et al., "The phenotypic characteristics of heterozygous reeler mouse", NEUROREPORT, 10(6), 1999, pp. 1329-1334

Abstract

Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-). These phenotypic traits are an similar to 50% decrease of brain Rein mRNA and Rein protein, an accumulation of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in subcortical white matter, an age-dependent decreasein prepulse inhibition of startle (PPI); and neophobic behavior on the elevated plus-maze. Possible analogies between these rl+/- phenotypic traits and signs of psychosis vulnerability are discussed. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:32:58