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Titolo:
DNA methylation at the putative promoter region of the human dopamine D2 receptor gene
Autore:
Popendikyte, V; Laurinavicius, A; Paterson, AD; Macciardi, F; Kennedy, JL; Petronis, A;
Indirizzi:
Univo,oronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Clarke Div, Toront Univ Toronto Toronto ON Canada M5T 1R8 eurogenet Sect, Clarke Div, Toront Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada Univ Toronto Toronto ON Canada M5T 1R8 chiat, Toronto, ON M5T 1R8, Canada Inst Biotechnol, LT-2028 Vilnius, Lithuania Inst Biotechnol Vilnius Lithuania LT-2028 ol, LT-2028 Vilnius, Lithuania Ctr Pathol, LT-2021 Vilnius, Lithuania Ctr Pathol Vilnius Lithuania LT-2021 Pathol, LT-2021 Vilnius, Lithuania
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1249 - 1255
SICI:
0959-4965(19990426)10:6<1249:DMATPP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; BASAL GANGLIA; BINDING; SITES; TOMOGRAPHY; CPG;
Keywords:
alcoholism; bisulphite modification; DNA methylation; dopamine D2 receptor gene (DRD2); epigenetics; post-mortem tissues; schizophrenia; striatum; tissue specificity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Petronis, A Univlloronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Clarke Div, 250 Co Univ Toronto 250 Coll St Toronto ON Canada M5T 1R8 Div, 250 Co
Citazione:
V. Popendikyte et al., "DNA methylation at the putative promoter region of the human dopamine D2 receptor gene", NEUROREPORT, 10(6), 1999, pp. 1249-1255

Abstract

DNA methylation was investigated in the putative promoter region of the human dopamine D2 receptor gene (DRD2). Twenty-two DNA samples from two typesof cells differentially expressing D2 receptors, striatum and lymphocytes,were subjected to bisulphite modification-based mapping of methylated cytosines. In the tested region, the DNA from lymphocytes exhibited a significantly higher degree of methylation than that from striata. In addition, a significantly higher proportion of methylated to unmethylated cytosines was detected in DRD2 from the right than the left striatum, and a trend towards a greater degree of methylation was detected in older than in younger individuals. These DRD2 methylation findings are consistent with dopamine D2 receptor binding data from the literature which support the idea that DNA methylation plays a role in regulation of DRDZ expression. (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 20/01/20 alle ore 04:50:38