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Titolo:
Galanin expression is decreased by cAMP-elevating agents in cultured sympathetic ganglia
Autore:
Mohney, RP; Zigmond, RE;
Indirizzi:
Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1221 - 1224
SICI:
0959-4965(19990426)10:6<1221:GEIDBC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMAFFIN CELLS; GENE-EXPRESSION; PROTEIN-KINASE; PEPTIDE; TRANSCRIPTION; PROMOTER; NEURONS; INCREASES; SEQUENCE; AXOTOMY;
Keywords:
axotomy; explant culture; gene expression; isoproterenol; nerve injury; superior cervical ganglion; vasoactive intestinal peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Zigmond, RE Case4106tern Reserve Univ, Dept Neurosci, 10900 Euclid Ave, Cleveland, OH 4 Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
R.P. Mohney e R.E. Zigmond, "Galanin expression is decreased by cAMP-elevating agents in cultured sympathetic ganglia", NEUROREPORT, 10(6), 1999, pp. 1221-1224

Abstract

GALANIN expression is co-regulated in peripheral neurons with that of vasoactive intestinal peptide (VIP) under a variety of conditions. For example,the expression of both increase after explantation of adult rat superior cervical ganglia (SCG). Because VIP participates in a positive feedback loopregulating its own expression, we examined whether VIP also increases galanin expression. Galanin mRNA and peptide are nearly undetectable in the SCGin vivo, but increase dramatically after 24-48 h in organ culture. Addition off VIP or forskolin to the culture medium reduced galanin mRNA expression by 75% and 77%, respectively, and reduced galanin peptide expression by 76% and 82%, respectively, compared with ganglia cultured in control medium. In contrast, isoproterenol stimulation did not significantly alter levels of galanin mRNA or peptide, consistent with previous observations that isoproterenol exerts its effect on SCG non-neuronal cells, but not on neurons. The results indicate that galanin and VIP are differentially regulated in sympathetic neurons by cAMP- elevating agents. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:02:28