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Titolo:
Serotonin-6 receptor variant (C267T) and clinical response to clozapine
Autore:
Yu, YWY; Tsai, SJ; Lin, CH; Hsu, CP; Yang, KH; Hong, CJ;
Indirizzi:
Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan Vet Gen Hosp Taipei Taiwan 11217 sp, Dept Psychiat, Taipei 11217, Taiwan Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 , Div Psychiat, Taipei 112, Taiwan
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1231 - 1233
SICI:
0959-4965(19990426)10:6<1231:SRV(AC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; 5-HT2A RECEPTOR; LOCALIZATION; CLONING; GENES;
Keywords:
clozapine; phamacogenetic; polymorphism; schizophrenia; serotonin 5-HT6 receptor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hong, CJ Vet Gen Hosp, Dept Psychiat, 201 Shih Pai Rd,Sec 2, Taipei 11217,Taiwan Vet Gen Hosp 201 Shih Pai Rd,Sec 2 Taipei Taiwan 11217 7, Taiwan
Citazione:
Y.W.Y. Yu et al., "Serotonin-6 receptor variant (C267T) and clinical response to clozapine", NEUROREPORT, 10(6), 1999, pp. 1231-1233

Abstract

CLOZAPINE is an effective atypical antipsychotic that has high affinity for serotonin type 6 receptors (5HT(6)). We tested the hypothesis that clinical response to clozapine in patients refractory to typical antipsychotic treatment is related to the genetic variant (C267T) of the 5HT(6) receptors. Ninety-nine schizophrenic patients with a history of non-response to typical antipsychotics were included in the study. The results demonstrated a modest but significant relationship between presence of the variant of the 5HT(6) receptors and the response to clozapine in these patients. Patients with homogenous 267T/T genotype had a better response than other patients. Although replication is required, these results suggest that the 5HT(6) receptor C267T polymorphism may be involved in clozapine response, especially in patients with anxious or depressed symptoms. (C) 1999 Lippincott Williams &Wilkins.

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Documento generato il 04/07/20 alle ore 18:26:42