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Titolo:
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
Autore:
Jonsson, EG; Nothen, MM; Grunhage, F; Farde, L; Nakashima, Y; Propping, P; Sedvall, GC;
Indirizzi:
Karolinskadenst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Swe Karolinska Inst Stockholm Sweden SE-17176 rosci, SE-17176 Stockholm, Swe Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 , Inst Human Genet, D-53111 Bonn, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 4, anno: 1999,
pagine: 290 - 296
SICI:
1359-4184(199905)4:3<290:PITDDR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 RACLOPRIDE BINDING; POSITRON CAMERA SYSTEM; LIVING HUMAN BRAIN; ALLELIC ASSOCIATION; EMISSION TOMOGRAPHY; DEPENDENT SUBJECTS; D-2 RECEPTORS; DRD2 LOCUS; A1 ALLELE; IN-VIVO;
Keywords:
DRD2; polymorphisms; association; PET; receptor binding; [C-11]raclopride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsson, EG Karolinskadenst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Swe Karolinska Inst Stockholm Sweden SE-17176 176 Stockholm, Swe
Citazione:
E.G. Jonsson et al., "Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers", MOL PSYCHI, 4(3), 1999, pp. 290-296

Abstract

The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic orenvironmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dopamine D2 receptor density in vivo, as measured by positron emission tomography and [C-11]raclopride in 56 healthy subjects. There was a significant association between presence of a putative functional DRD2 promoter allele (-141C Del) and high striatal dopamine receptor density (t = 2.32, P = 0.02). In agreement with some previous studies(2-4) the presence of the DRD2 TaqIAl allele was associated with measures of low dopamine receptor density (t =2.58, P = 0.01). Also the DRD2 TaqIB1 allele was associated with low dopamine receptor density (t = 2.58, P = 0.01) whereas there was no significant relationship between another common silent intronic DRD2 short tandem repeat polymorphism (STRP) and striatal dopamine D2 receptor density. The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects. Theresults should be interpreted with caution because of the limited sample size.

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Documento generato il 21/01/20 alle ore 00:56:35