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Titolo:
Potential role of platelet activating factor in acute renal failure
Autore:
Lopez-Novoa, JM;
Indirizzi:
Univamancaanca, Dept Fisiol & Farmacol, Inst Reina Sofia Invest Nefrol, Sal Univ Salamanca Salamanca Spain 37007 Inst Reina Sofia Invest Nefrol, Sal
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 55, anno: 1999,
pagine: 1672 - 1682
SICI:
0085-2538(199905)55:5<1672:PROPAF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT MESANGIAL CELLS; ACETYL GLYCERYL ETHER; CYCLOSPORINE-INDUCED NEPHROTOXICITY; ISCHEMIA-REPERFUSION INJURY; ATRIAL-NATRIURETIC-PEPTIDE; FACTOR ANTAGONIST; PAF-ANTAGONIST; HYPERACUTE REJECTION; INDUCED PANCREATITIS; PATHO-PHYSIOLOGY;
Keywords:
glomerular filtration rate; renal injury; PAF; acetylated alkyl phosphoglycerides; hemodynamics;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Lopez-Novoa, JM Univpuslamanca, Dept Fisiol & Farmacol, Inst Reina Sofia Invest Nefrol, Cam Univ Salamanca Campus Unamuno,Edificio Departamental Salamanca Spain 37007
Citazione:
J.M. Lopez-Novoa, "Potential role of platelet activating factor in acute renal failure", KIDNEY INT, 55(5), 1999, pp. 1672-1682

Abstract

The clinical condition of acute renal failure (ARF) can be caused by a diverse number of renal injuries, but it is generally characterized by a sharpreduction in the glomerular filtration rate (GFR). A lipid mediator, platelet activating factor (PAF), may be one of the entities responsible for causing the hemodynamic changes in the ARF kidney because it can act as a vasodilator or vasoconstrictor, depending upon its concentration. This review examines the action and mechanisms of PAF in experimental animal models of ischemia and nephrotoxicity, as well as renal failure associated with extrarenal diseases. While further research is necessary before extrapolating ourcurrent knowledge of PAF into the prevention of renal failure or therapeutic intervention using PAF antagonists in human ARF, there is reasonable evidence to support its role as a mediator of the decrease in GFR characteristic of ARF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:21:23