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Titolo:
HLA-derived peptides as novel immunomodulatory therapeutics
Autore:
Murphy, B; Krensky, AM;
Indirizzi:
Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pediat, Stanford, CA 94305 USA CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 t Med, New York, NY 10029 USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 6, volume: 10, anno: 1999,
pagine: 1346 - 1355
SICI:
1046-6673(199906)10:6<1346:HPANIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RECOGNITION; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES; ANTIGEN-PRESENTING CELLS; SKIN ALLOGRAFT SURVIVAL; HEART GRAFT-SURVIVAL; CLASS-II-BINDING; V-BETA GENES; CYCLOSPORINE-A; MHC PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Krensky, AM Stanford Univ, Sch Med, Dept Pediat, 300 Pasteur Dr, Stanford,CA 94305 USA Stanford Univ 300 Pasteur Dr Stanford CA USA 94305 A 94305 USA
Citazione:
B. Murphy e A.M. Krensky, "HLA-derived peptides as novel immunomodulatory therapeutics", J AM S NEPH, 10(6), 1999, pp. 1346-1355

Abstract

A growing body of experimental evidence demonstrates that synthetic peptides corresponding to linear sequences of MHC (HLA in humans) proteins have immunomodulatory effects in vitro and in vivo in animal models and in humans. Although the original concept was that these peptides inhibited antigen recognition at the MHC-T cell receptor interface via physical blockade, it is now clear that the mechanisms responsible for the myriad of functional effects are more complex. Recent findings show that some peptides affect signal transduction and cell cycle progression. Fragments of MHC molecules can dampen or downregulate immune responses via a variety of mechanisms. Some soluble MHC molecules or synthetic peptides are capable of inducing and maintaining immunologic tolerance in animals. This information suggests that synthetic peptides themselves or drugs mimicking their effects may represent a new class of immunotherapeutics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:29:12