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Titolo:
Effects of in vitro cadmium exposure on ovarian steroidogenesis in rats
Autore:
Piasek, M; Laskey, JW;
Indirizzi:
Inst Med Res & Occupat Hlth, Mineral Metab Unit, HR-10001 Zagreb, Croatia Inst Med Res & Occupat Hlth Zagreb Croatia HR-10001 0001 Zagreb, Croatia US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA
Titolo Testata:
JOURNAL OF APPLIED TOXICOLOGY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 211 - 217
SICI:
0260-437X(199905/06)19:3<211:EOIVCE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLING RATS; OVULATION; CHLORIDE; PROGESTERONE; SECRETION; GRANULOSA; PITUITARY; ADRENALS; CULTURE; INVITRO;
Keywords:
cadmium; estrus cycle; ovarian culture; pregnancy; rat; specific radioimmunoassay; steroid hormone production;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Piasek, M Inst-10001es & Occupat Hlth, Mineral Metab Unit, 2 Ksaverska St,POB 291, HR Inst Med Res & Occupat Hlth 2 Ksaverska St,POB 291 Zagreb Croatia HR-10001
Citazione:
M. Piasek e J.W. Laskey, "Effects of in vitro cadmium exposure on ovarian steroidogenesis in rats", J APPL TOX, 19(3), 1999, pp. 211-217

Abstract

The purpose of this study was to evaluate the direct effect(s) of in vitrocadmium (Cd) exposure on steroidogenesis in rat ovaries during different reproductive states. Sprague-Dawley rats were killed on the day of proestrus, or on gestation day 6 or 16, Ovaries were removed, placed in medium and minced, Culture from each ovary was incubated with Cd2+ ions in concentrations of 0, 100, 500, 1000, 1500, or 2000 mu M. One-hour whole-ovary production of progesterone (P-4), testosterone and estradiol (E-2) in culture mediumwas evaluated in the absence and presence of human chorionic gonadotropin (hCG) or hCG plus pregnenolone by specific radioimmunoassay, Under in vitroCd exposure the most affected were productions of P-4 and testosterone in proestrus rats and less in pregnant dams, whereas E-2 was not affected at all. Cadmium appears to interfere with the ovarian steroidogenic pathway in rats at more than one site. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:52:09