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Titolo:
LONG-TERM INTRACEREBROVENTRICULAR INFUSION OF CORTICOTROPIN-RELEASINGHORMONE ALTERS NEUROENDOCRINE NEUROCHEMICAL, AUTONOMIC, BEHAVIORAL, AND CYTOKINE RESPONSES TO A SYSTEMIC INFLAMMATORY CHALLENGE
Autore:
LINTHORST ACE; FLACHSKAMM C; HOPKINS SJ; HOADLEY ME; LABEUR MS; HOLSBOER F; REUL JMHM;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT NEUROENDOCRINOL,SECT NEUROIMMUNOENDOCRINOL D-80804 MUNICH GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT NEUROENDOCRINOL,SECT NEUROIMMUNOENDOCRINOL D-80804 MUNICH GERMANY UNIV MANCHESTER,HOPE HOSP,CTR RHEUMAT DIS SALFORD M6 8HD LANCS ENGLAND
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 17, anno: 1997,
pagine: 4448 - 4460
SICI:
0270-6474(1997)17:11<4448:LIIOC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; MESSENGER-RIBONUCLEIC-ACID; FACTOR RECEPTORS; SEROTONERGIC NEUROTRANSMISSION; PARAVENTRICULAR NUCLEUS; ALZHEIMERS-DISEASE; DEPRESSED-PATIENTS; RAT-BRAIN; STRESS; CRF;
Keywords:
CORTICOTROPIN-RELEASING HORMONE; ENDOTOXIN; HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS; CORTICOSTERONE; BODY TEMPERATURE; SICKNESS BEHAVIOR; LOCOMOTION; SEROTONIN; HIPPOCAMPUS; INTERLEUKIN-1; INTERLEUKIN-6; IN VIVO MICRODIALYSIS; BIOTELEMETRY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
A.C.E. Linthorst et al., "LONG-TERM INTRACEREBROVENTRICULAR INFUSION OF CORTICOTROPIN-RELEASINGHORMONE ALTERS NEUROENDOCRINE NEUROCHEMICAL, AUTONOMIC, BEHAVIORAL, AND CYTOKINE RESPONSES TO A SYSTEMIC INFLAMMATORY CHALLENGE", The Journal of neuroscience, 17(11), 1997, pp. 4448-4460

Abstract

Corticotropin-releasing hormone (CRH) was infused intracerebroventricularly into rats for 7 d via a miniosmotic pump (1 mu g .mu l(-1). hr(-1)). Body temperature and locomotor activity were recorded during thetreatment using biotelemetry, whereas hippocampal serotonergic neurotransmission and free corticosterone levels were monitored using in vivo microdialysis on day 7 of CRH treatment. During the microdialysis experiment, behavioral activity was scored by assessing the time during which rats were active (locomotion, grooming, eating, drinking). Continuous intracerebroventricular infusion of CRH produced a transient increase in body temperature and locomotion. Moreover, intracerebroventricularly CRH-treated rats showed elevated free corticosterone levels with no apparent diurnal rhythm. Intraperitoneal administration of bacterial endotoxin [lipopolysaccharide (LPS); 100 mu g/kg body weight] on day 7 of CRH/vehicle treatment produced a marked fever response in control animals, which was significantly blunted in intracerebroventricularly CRH-treated rats. Although free corticosterone levels reached similar peak concentrations in both intracerebroventricularly vehicle- and CRH-infused groups after LPS, this response was delayed significantly by similar to 1 hr in the intracerebroventricularly CRH-treated animals. Microdialysis experiments showed no changes in basal extracellular levels of serotonin and 5-hydroxyindoleacetic acid in intracerebroventricularly CRH-infused animals. Injection of LPS in intracerebroventricularly CRH-treated rats produced a blunted 5-HT response and a delayed onset of behavioral inhibition and other signs of sickness behavior. Assessment of the endotoxin-induced cytokine responses showed significantly enhanced plasma interleukin-1 (IL-1) and IL-6 bioactivities inthe intracerebroventricularly CRH-infused animals 3 hr after injection of LPS, whereas tumor necrosis factor bioactivity responses were notdifferent.Our data demonstrate that chronically elevated brain CRH levels produce marked changes in basal (largely CRH regulated) physiological and behavioral processes accompanied by aberrant responses to an acute challenge. The present study provides evidence that chronic CRH hypersecretion is an important factor in the etiology of stress-related disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:37:35