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Titolo:
Differential B- and T-cell activation in Wegener's granulomatosis
Autore:
Popa, ER; Stegeman, CA; Bos, NA; Kallenberg, CGM; Tervaert, JWC;
Indirizzi:
Univ Groningen Hosp, Dept Clin Immunol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Groningen Hosp, Dept Nephrol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Groningen, Dept Histol & Cell Biol, NL-9700 AB Groningen, NetherlandsUniv Groningen Groningen Netherlands NL-9700 AB B Groningen, Netherlands
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 103, anno: 1999,
parte:, 1
pagine: 885 - 894
SICI:
0091-6749(199905)103:5<885:DBATAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; CYTOPLASMIC ANTIBODY TITER; INTERLEUKIN-2 RECEPTOR; VASCULITIS; AUTOANTIBODIES; RELAPSES; MARKERS; BLOOD; ANCA; PREVENTION;
Keywords:
Wegener's granulomatosis; immunology; B cells; T cells; activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Popa, ER Univ Groningen Hosp, Dept Clin Immunol, Hanzeplein 1, NL-9713 GZ Groningen, Univ Groningen Hosp Hanzeplein 1 Groningen Netherlands NL-9713 GZ
Citazione:
E.R. Popa et al., "Differential B- and T-cell activation in Wegener's granulomatosis", J ALLERG CL, 103(5), 1999, pp. 885-894

Abstract

Background: Autoimmune mechanisms are postulated to play a role in the development and progression of Wegener's granulomatosis (WG), a form of systemic, idiopathic necrotizing vasculitis,Objective: We investigated the relation between lymphocyte activation and disease activity in patients with WG, Methods: B- and T-lymphocyte activation was studied by cytometric assessment of the expression of the activationmarkers CD38 on B cells and CD25 and HLA-DR on CD4(+) and CD8(+) T-cell subsets, respectively. Activation at the cellular level was related to serum levels of antineutrophil cytoplasmic antibodies and soluble IL-2 receptor, which can be regarded as soluble activation markers of B and T cells. Results: Percentages of CD38(bright) activated B cells were higher in patients with active WG than in patients experiencing disease remission (P < .05) or in healthy control subjects (P < .05), Percentages of activated CD4(+) and CD8(+) T cells were higher in patients with active WG (CD4 subset, P < .0001; CD8 subset, P < .005) than in healthy individuals, An increased percentage of activated T cells of both subsets was also seen in patients whose condition was in remission, as compared with healthy control subjects (CD4 subset, P < .0005; CD8 subset, P < .001). Lymphocyte activation at the cellular level did not correlate with plasma levels of antineutrophil cytoplasmic antibodies or soluble IL-2 receptor. Conclusion: In WG, B-cell activation is related to active disease, whereasT-cell activation persists during remission of the disease, which points to an intrinsic disordered immune system in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:23:48