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Titolo:
VASOPRESSIN SEROTONIN INTERACTIONS IN THE ANTERIOR HYPOTHALAMUS CONTROL AGGRESSIVE-BEHAVIOR IN GOLDEN-HAMSTERS/
Autore:
FERRIS CF; MELLONI RH; KOPPEL G; PERRY KW; FULLER RW; DELVILLE Y;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,DEPT PSYCHIAT,NEUROPSYCHIAT SCI PROGRAM,55LAKE AVE N WORCESTER MA 01655 ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS INDIANAPOLIS IN 46285
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 17, anno: 1997,
pagine: 4331 - 4340
SICI:
0270-6474(1997)17:11<4331:VSIITA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLANK-MARKING BEHAVIOR; CEREBROSPINAL-FLUID MONOAMINE; LOW CSF 5-HIAA; ADENYLATE-CYCLASE; RAT-BRAIN; 5-HYDROXYINDOLEACETIC ACID; IMPULSIVE AGGRESSION; AMINE METABOLITES; V1-LIKE RECEPTOR; 5-HT1B RECEPTORS;
Keywords:
FLUOXETINE; VASOPRESSIN; SEROTONIN; ANTERIOR HYPOTHALAMUS; OFFENSIVE AGGRESSION; V-1A RECEPTOR; 5-HT1B RECEPTOR; SERENIC; FLANK MARKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Ferris et al., "VASOPRESSIN SEROTONIN INTERACTIONS IN THE ANTERIOR HYPOTHALAMUS CONTROL AGGRESSIVE-BEHAVIOR IN GOLDEN-HAMSTERS/", The Journal of neuroscience, 17(11), 1997, pp. 4331-4340

Abstract

Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V-1A receptor facilitates offensive aggression,i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V-1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactiveAVP and 5-HT fibers and putative terminals. Putative 5-HT synapses onAVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HTat the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latenciesto bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP toincrease offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:09:42