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Titolo:
Lowered entrainment function in the suprachiasmatic nucleus of Otsuka LongEvans Tokushima Fatty (OLETF) rats
Autore:
Shimazoe, T; Maetani, M; Nakamura, S; Yamanouchi, S; Watanabe, S; Miyasaka, K; Kono, A; Funakoshi, A;
Indirizzi:
Kyushu Univ 62, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8128582, JapanKyushu Univ 62 Fukuoka Japan 8128582 t Pharmacol, Fukuoka 8128582, Japan Tokyo Metropolitan Inst Gerontol, Dept Clin Physiol, Tokyo 1730015, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730015 okyo 1730015, Japan Kyushu Natl Canc Ctr, Fukuoka 8111395, Japan Kyushu Natl Canc Ctr Fukuoka Japan 8111395 c Ctr, Fukuoka 8111395, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 80, anno: 1999,
pagine: 85 - 88
SICI:
0021-5198(199905)80:1<85:LEFITS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVITY RHYTHM; DIABETIC RATS; RECEPTOR AGONIST; FOS EXPRESSION; C-FOS; PHASE; SEROTONIN;
Keywords:
Otsuka Long Evans Tokushima Fatty (OLETF) rat; suprachiasmatic nucleus; entrainment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Shimazoe, T Kyushu Univ 62, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8128582, Japan Kyushu Univ 62 Fukuoka Japan 8128582 Fukuoka 8128582, Japan
Citazione:
T. Shimazoe et al., "Lowered entrainment function in the suprachiasmatic nucleus of Otsuka LongEvans Tokushima Fatty (OLETF) rats", JPN J PHARM, 80(1), 1999, pp. 85-88

Abstract

The entrainment function,ia the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETFrats significantly needed more days for re-entrainment to a new light-darkcycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 mu M glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:11:52