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Titolo:
CONTROLLED OPIOID WITHDRAWAL EVALUATION DURING 72 H DOSE OMISSION IN BUPRENORPHINE-MAINTAINED PATIENTS
Autore:
EISSENBERG T; JOHNSON RE; BIGELOW GE; WALSH SL; LIEBSON IA; STRAIN EC; STITZER ML;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,DIV BEHAV BIOL,BEHAV PHARMACOL RES UNIT BALTIMORE MD 21224
Titolo Testata:
Drug and alcohol dependence
fascicolo: 1-2, volume: 45, anno: 1997,
pagine: 81 - 91
SICI:
0376-8716(1997)45:1-2<81:COWED7>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEROIN-ADDICTS; CLINICAL-TRIAL; DEPENDENCE; METHADONE; BLOCKADE; HUMANS; DETOXIFICATION; PHARMACOLOGY; CLONIDINE; AGONIST;
Keywords:
BUPRENORPHINE; LESS-THAN-DAILY-DOSING; OPIOID ANTAGONISTS; ANTAGONIST-PRECIPITATED WITHDRAWAL; PHYSICAL DEPENDENCE; SPONTANEOUS WITHDRAWAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
T. Eissenberg et al., "CONTROLLED OPIOID WITHDRAWAL EVALUATION DURING 72 H DOSE OMISSION IN BUPRENORPHINE-MAINTAINED PATIENTS", Drug and alcohol dependence, 45(1-2), 1997, pp. 81-91

Abstract

Buprenorphine's clinical utility as an opioid dependence pharmacotherapy may be enhanced with less-than-daily dosing. This study assessed opioid withdrawal after an acute 72 h dose omission in buprenorphine-maintained patients (8 mg/day s.l.). Eight outpatients required to remain free of opioids, cocaine and benzodiazepines completed four double-blind, double-dummy, Latin-square ordered conditions. Test conditions of 8 or 16 mg s.l. buprenorphine were followed by 2 days of placebo dosing. Control conditions were buprenorphine maintenance (8 mg/day), to provide a reference for evaluation of placebo test days and naloxone administration (10 mg/70 kg i.m.) during 8 mg buprenorphine maintenanceto assess withdrawal measure sensitivity. Subjective measures and pupil diameter were significantly influenced only by naloxone. The lack of subjective symptoms and physiological signs of opioid withdrawal during 72 h of acute dose omission supports the feasibility of less-than-daily dosing at buprenorphine doses of 8 mg/day in patients who have demonstrated an ability to remain drug-free for an extended period. (C)1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:34:05