Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF PAST HISTORY OF MAJOR DEPRESSION ON SMOKING CHARACTERISTICS, MONOAMINE OXIDASE-A AND OXIDASE-B ACTIVITIES AND WITHDRAWAL SYMPTOMS IN DEPENDENT SMOKERS
Autore:
BERLIN I; SPREUXVAROQUAUX O; SAID S; LAUNAY JM;
Indirizzi:
HOP LA PITIE SALPETRIERE,DEPT CLIN PHARMACOL,47 BD HOP F-75013 PARIS FRANCE CTR HOSP VERSAILLES,PHARMACOL & TOXICOL CTR,DEPT BIOCHEM LE CHESNAY FRANCE HOP LARIBOISIERE,DEPT BIOCHEM F-75475 PARIS FRANCE
Titolo Testata:
Drug and alcohol dependence
fascicolo: 1-2, volume: 45, anno: 1997,
pagine: 31 - 37
SICI:
0376-8716(1997)45:1-2<31:EOPHOM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET MAO ACTIVITY; CIGARETTE SMOKERS; NICOTINE DEPENDENCE; BLOOD-PLATELETS; CESSATION; PLASMA; RESPONSIVENESS; CLONIDINE; DISORDERS; SUBTYPES;
Keywords:
DEPENDENT SMOKERS; PAST HISTORY OF DEPRESSION; MONOAMINE OXIDASES; WITHDRAWAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
I. Berlin et al., "EFFECTS OF PAST HISTORY OF MAJOR DEPRESSION ON SMOKING CHARACTERISTICS, MONOAMINE OXIDASE-A AND OXIDASE-B ACTIVITIES AND WITHDRAWAL SYMPTOMS IN DEPENDENT SMOKERS", Drug and alcohol dependence, 45(1-2), 1997, pp. 31-37

Abstract

Past history of major depression is more common in smokers than in non-smokers. We have shown in a previous study that lifetime prevalence of major depression is higher in dependent smokers and they have lowermonoamine oxidase-A and -B activities than non-smokers. Because several studies have found an association between MAO-B activity and depression we analysed data of these smokers to assess:whether past history of major depression is associated with reduced monoamine oxidase activities (A and B) or not. Further, we tried to characterize smokers withpast history of major depression and its effect on withdrawal symptoms. The data of 88 dependent smokers (Fagerstrom Tolerance Questionnaire score greater than or equal to 6 and smoking greater than or equal to 20 cigarettes/day) who participated in a smoking cessation study were analysed. Smokers with past history of major depression but without current illness did not differ in demographic and smoking characteristics from smokers without past history of major depression. Smokers with past history of major depression were mainly women and had lower body mass index. Adjusted for gender and body mass index dependent smokers with or without past history of depression had similar MAO-A and MAO-B activities but smokers with past history of major depression had significantly lower resting plasma norepinephrine levels. Smokers with past history of depression had not significantly higher ratings for depression (Montgomery-Asberg Depression Rating Scales) and anxiety (Hamilton Anxiety Scales) and smoking cessation did not exacerbate these ratings (assessed up to 3 months) and none had depressive episode duringthe postcessation period up to one year. Past history of depression was associated with higher scores on 'expressed sadness' and 'depressive mood'. Abstinent smokers with past history of depression had significantly higher ratings in one of the seven ratings of a 6 months periodfor craving (day 28), anxiety (day 7) and total withdrawal symptom score (day 7) when compared to those who had no past history of major depression. It is concluded that (i) past history of major depression ismore frequent in female smokers (ii) smokers with past history of depression may have more intense withdrawal symptoms (craving and anxiety) at some time after cessation; and (iii) past history of depression does not affect monoamine oxidase activities, therefore, reduced monoamine oxidase activities found in previous studies are possibly characteristic features of smoking. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:43:23