Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells
Autore:
Bermudez, LE; Petrofsky, M;
Indirizzi:
Univedalif San Francisco, Kuzell Inst Arthrit & Infect Dis, Calif Pacific M Univ Calif San Francisco San Francisco CA USA 94115 Dis, Calif Pacific M
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 6, volume: 67, anno: 1999,
pagine: 3108 - 3111
SICI:
0019-9567(199906)67:6<3108:HDAMAD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; TUBERCULOSIS INFECTION; HUMAN MACROPHAGES; GAMMA-INTERFERON; MICE; EXPRESSION; RESISTANCE; GROWTH; INTERLEUKIN-12; NECROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez, LE Univedalif San Francisco, Kuzell Inst Arthrit & Infect Dis, Calif Pacific M Univ Calif San Francisco 2200 Webster St,Suite 305 San Francisco CA USA 94115
Citazione:
L.E. Bermudez e M. Petrofsky, "Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells", INFEC IMMUN, 67(6), 1999, pp. 3108-3111

Abstract

The role of CD8(+) T cells was evaluated in a mouse model of disseminated Mycobacterium avium infection. C57BL/6J and C57BL/6J beta(2)(-/-) (beta(2)(-/-)) mice were infected intravenously, and the number of viable bacteria in each liver and spleen was determined. No significant difference between the number of bacteria in the two strains of mice was observed at 2, 4, 6, and 8 weeks after infection. Histopathological examination of granulomas from C57BL/6J and beta(2)(-/-) mice did not show any difference either in the number of organisms per granuloma or in the size of the granulomas, Investigation of the cytokine profile in the spleen demonstrated that the beta(2)(-/-) strain of mice produced a significantly lower amount of gamma interferon at 8 weeks after infection and significantly increased concentrations oftumor necrosis factor alpha compared with that from the wild-type mouse. Interleukin-12 and transforming growth factor beta(1) levels did not differ between the two strains of mice at 2, 4, 6, and 8 weeks. Although previous work had found that host response against Mycobacterium tuberculosis involves major histocompatibility complex class I-restricted T cells, our resultsindicate that chronic deficiency of CD8(+) T cells does not lead to a different expression of the disease and that if CD8(+) T cells are involved in the host response, their function can be assumed by other immune cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:57:56