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Titolo:
Acute clinical disease in cats following infection with a pathogenic strain of Bartonella henselae (LSU16)
Autore:
OReilly, KL; Bauer, RW; Freeland, RL; Foil, LD; Hughes, KJ; Rohde, KR; Roy, AF; Stout, RW; Triche, PC;
Indirizzi:
Louisianauge,te Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Ro Louisiana State Univ Baton Rouge LA USA 70803 obiol & Parasitol, Baton Ro LouisianaSAtate Univ, Sch Vet Med, Dept Vet Pathol, Baton Rouge, LA 70803 U Louisiana State Univ Baton Rouge LA USA 70803 ol, Baton Rouge, LA 70803 U LouisianaUSAate Univ, Sch Vet Med, Div Lab Anim Med, Baton Rouge, LA 70803Louisiana State Univ Baton Rouge LA USA 70803 Med, Baton Rouge, LA 70803 Louisiana State Univ, Dept Entomol, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 6, volume: 67, anno: 1999,
pagine: 3066 - 3072
SICI:
0019-9567(199906)67:6<3066:ACDICF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCRATCH DISEASE; BACILLARY ANGIOMATOSIS; DOMESTIC CATS; ROCHALIMAEA; ENCEPHALOPATHY; BACTEREMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: O'Reilly, KL Louisianauge,te Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Ro Louisiana State Univ Baton Rouge LA USA 70803 itol, Baton Ro
Citazione:
K.L. O'Reilly et al., "Acute clinical disease in cats following infection with a pathogenic strain of Bartonella henselae (LSU16)", INFEC IMMUN, 67(6), 1999, pp. 3066-3072

Abstract

Bartonella henselae is the causative agent of human cat scratch disease aswell as several serious sequelae of infections, including bacillary angiomatosis and bacillary peliosis, Conflicting reports describe the pathogenesis of B. henselae in the cat. In this study, we characterized a strain of B.henselae termed LSU16. This strain was isolated on rabbit blood agar from a naturally infected 10-month-old female cat during a recurrent episode of bacteremia, The bacterial species was confirmed by PCR-restriction fragmentlength polymorphism analysis. Nine cats were infected intradermally with 5x 10(7) CFU of LSU16, and clinical signs, antibody responses, and bacteremia were monitored. All nine cats developed raised, erythematous areas at the site of inoculation within 72 h postinoculation; the swelling peaked at 14 days postinfection and was not palpable by 28 days postinfection, Fever developed in all nine cats between 6 and 16 days postinfection and lasted for 1 to 8 days. Between 6 and 16 days postinfection, all nine cats experienced lethargy which persisted 5 to 18 days. Seven of nine eats were bacteremic by day 7, and all nine cats had become bacteremic by 14 days postinfection. Bacteremia peaked at 14 to 28 days postinfection in all cats. In six of the nine infected cats, bacterial numbers reached nondetectable levels during the 7th week postinfection; however, a single animal maintained bacteremia to 18 weeks postinfection. All nine cats developed strong antibody responses to B. henselae, as determined by Western blot analysis and enzyme-linked immunosorbent assay. Subsequently, three naive cats were injected intradermally with blood front cats infected with LSU16 from a pure culture, and five naive cats were injected with feces from fleas which had been feeding on cats infected with a pure culture of LSU16. These cats developed signs similar to those described in the previous experiment and were euthanized at5 weeks postinfection, We conclude that B. henselae LSU16 is a virulent strain of B. henselae in cats and propose that the virulence of B. henselae in cats is strain dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 01:09:00