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Titolo:
MOLECULAR-CLONING OF A NEW UNC-33-LIKE CDNA FROM RAT-BRAIN AND ITS RELATION TO PARANEOPLASTIC NEUROLOGICAL SYNDROMES
Autore:
QUACH TT; RONG YG; BELIN MF; DUCHEMIN AM; AKAOKA H; DING SL; BAUDRY M; KOLATTUKUDY PE; HONNORAT J;
Indirizzi:
OHIO STATE UNIV,NEUROBIOTECHNOL CTR,1060 CARMACK RD COLUMBUS OH 43210 FAC MED LAENNEC,INSERM,U433 F-69008 LYON FRANCE UNIV SO CALIF,DEPT NEUROBIOL LOS ANGELES CA 90089 OHIO STATE UNIV,MED CTR,DEPT PSYCHIAT COLUMBUS OH 43210
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 46, anno: 1997,
pagine: 329 - 332
SICI:
0169-328X(1997)46:1-2<329:MOANUC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; GENE; OUTGROWTH; TOAD-64;
Keywords:
UNC-33-LIKE CDNA; GENE EXPRESSION; BRAIN SPECIFICITY; ANTI-CV2-AUTOANTIBODY; PARANEOPLASTIC NEUROLOGICAL SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T.T. Quach et al., "MOLECULAR-CLONING OF A NEW UNC-33-LIKE CDNA FROM RAT-BRAIN AND ITS RELATION TO PARANEOPLASTIC NEUROLOGICAL SYNDROMES", Molecular brain research, 46(1-2), 1997, pp. 329-332

Abstract

Anti-CV2-autoantibodies from patients with paraneoplastic neurological syndromes were used to purify protein(s) related to this disease. A novel cDNA, c-22, was obtained by PCR with primers based on amino-acidsequence of peptides obtained from this protein and rat brain cDNA astemplate. The deduced amino-acid sequence of c-22 shows homology to the Unc-33 gene from C. elegans in which mutations lead to defects in neuritic outgrowth and axonal guidance and cause uncoordinated movements of the nematode. Several consensus sites for putative protein kinaseC phosphorylation were found, suggesting that the c-22 gene product may be a phosphoprotein. Northern hybridizations show that the apparently unique 3.8-kb mRNA of c-22 is present in rat brain tissue and its expression is developmentally regulated: the levels of C-22 mRNA, detectable in brain at embryonic day 17 (E17), increase up to post-natal day 7 (P7) and decline rapidly to an almost undetectable level in adult.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:55:56