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Titolo:
The Acid phosphatase-1 gene region in the Drosophila species of the subobscura cluster
Autore:
Navarro-Sabate, A; Aguade, M; Segarra, C;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
HEREDITAS
fascicolo: 1, volume: 130, anno: 1999,
pagine: 65 - 75
SICI:
0018-0661(1999)130:1<65:TAPGRI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSCURA GROUP; EVOLUTIONARY RELATIONSHIPS; SYNONYMOUS SUBSTITUTIONS; MOLECULAR EVOLUTION; MELANOGASTER; DNA; POLYMORPHISM; NUCLEOTIDE; DIVERGENCE; DISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Segarra, C Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 08071 Barcelona, Spain
Citazione:
A. Navarro-Sabate et al., "The Acid phosphatase-1 gene region in the Drosophila species of the subobscura cluster", HEREDITAS, 130(1), 1999, pp. 65-75

Abstract

The acid phosphatase-1 (Acph-1) gene region was sequenced in three speciesof Drosophila: D. subobscura, D. madeirensis and D. guanche. These three closely related species, which are included in the obscura group, form the subobscura cluster. The different functional regions of the gene were identified by similarity with the sequence of D. melanogaster. The structure of Acph-1 is conserved in the four species. Average divergence at synonymous and nonsynonymous sites between D, melanogaster and the species of the subobscura cluster is K-s = 1.1354 and K-a = 0.1743, respectively. The rather high K-a value confirms that ACPH-1 is a rapidly evolving enzyme in Drosophila, as previously suggested by immunological studies. Amino acid replacementsare not randomly distributed along the gene. In fact, an excess of replacements is detected in exon I, indicating that the signal peptide encoded by this exon evolves even faster than the rest of the protein. Divergence at the Acph-1 gene region is further evidence that D. madeirensis and D. subobscura are more closely related than D, guanche is to any of them. In addition, both silent divergence in noncoding regions and synonymous divergence inthe coding region indicate that the split of the D. guanche lineage is about twice as old as the split of the lineages leading to D. madeirensis and D. subobscura. These phylogenetic relationships are, however, not supportedby divergence at nonsynonymous sites since the lowest K-a estimate is between D. guanche and D. subobscura.

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Documento generato il 04/12/20 alle ore 12:36:02