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Titolo:
Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: A meta-analysis
Autore:
Bernard, B; Grange, JD; Khac, EN; Amiot, X; Opolon, P; Poynard, T;
Indirizzi:
Hop La Pitie Salpetriere, Serv Hepatogastroenterol, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 rol, F-75651 Paris, France Hop Tenon, Serv Hepatogastroenterol, F-75970 Paris, France Hop Tenon Paris France F-75970 epatogastroenterol, F-75970 Paris, France
Titolo Testata:
HEPATOLOGY
fascicolo: 6, volume: 29, anno: 1999,
pagine: 1655 - 1661
SICI:
0270-9139(199906)29:6<1655:APFTPO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-DISEASE; CLINICAL-TRIALS; HEMORRHAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bernard, B Hop La Pitie Salpetriere, Serv Hepatogastroenterol, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 1 Paris, France
Citazione:
B. Bernard et al., "Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: A meta-analysis", HEPATOLOGY, 29(6), 1999, pp. 1655-1661

Abstract

cirrhotic patients with gastrointestinal bleeding, antibiotic prophylaxis decreases the incidence of infections but most randomized trials have not shown an increase in survival. The aim of this meta-analysis was to assess the efficacy of antibiotic prophylaxis in the prevention of infections and its effect on survival rate in cirrhotic patients with gastrointestinal bleeding. Four end points were assessed: infection, bacteremia and/or spontaneous bacterial peritonitis (SBP), incidence of SEP, and death. For each end point, heterogeneity and treatment efficacy were assessed by Der Simonian and Peto methods. Five trials including 534 patients, 264 treated with antibiotic prophylaxis for 4 to 10 days and 270 without, were identified. Mean follow-up was 12 days. Antibiotic prophylaxis significantly increased the mean percentage of patients free of infection (32% mean improvement rate, 95% confidence interval [CI]: 22-42, P < .001), bacteremia and/or SEP (19% meanimprovement rate, 95% CI: 11-26, P < .001), and SEP (7% mean improvement rate, 95% CI: 2.1-12.6, P = .006). Antibiotic prophylaxis also significantlyincreased the mean survival rate (9.1% mean improvement rate, 95 % CI: 2.9-15.3, P = .004), without significant heterogeneity. In cirrhotic patients with gastrointestinal bleeding, short-term antibiotic prophylaxis significantly increases the mean percentage of patients free of infection and significantly increases short-term survival rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:17:02