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Titolo:
Source(s) of activator calcium for noradrenaline-induced vasoconstriction in the perfused rabbit isolated ovarian vascular bed - A role for tyrosine kinase
Autore:
Yousif, MH; Williams, KI; Oriowo, MA;
Indirizzi:
Kuwait Univ, Fac Med, Dept Pharmacol, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 Med, Dept Pharmacol, Safat 13110, Kuwait Univ Bath, Dept Pharmacol, Sch Pharm, Bath BA2 7AY, Avon, England Univ Bath Bath Avon England BA2 7AY ch Pharm, Bath BA2 7AY, Avon, England
Titolo Testata:
GENERAL PHARMACOLOGY
fascicolo: 5, volume: 32, anno: 1999,
pagine: 563 - 570
SICI:
0306-3623(199905)32:5<563:SOACFN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; INOSITOL TRISPHOSPHATE; 2ND MESSENGERS; INHIBITION; RESPONSES; RAT; ALPHA-1-ADRENOCEPTOR; DIACYLGLYCEROL; CONTRACTION; ANTAGONISTS;
Keywords:
rabbit ovarian vascular bed; tyrosine kinase; protein kinase C; alpha(1)-adrenoceptors; calcium; nifedipine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yousif, MH Kuwait Univ, Fac Med, Dept Pharmacol, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 , Safat 13110, Kuwait
Citazione:
M.H. Yousif et al., "Source(s) of activator calcium for noradrenaline-induced vasoconstriction in the perfused rabbit isolated ovarian vascular bed - A role for tyrosine kinase", GEN PHARM, 32(5), 1999, pp. 563-570

Abstract

The effects of Ca2+ withdrawal and agents affecting Ca2+ translocation on alpha(1)-adrenoceptor-mediated vasoconstrictor responses in the perfused rabbit ovarian vascular bed were studied. Noradrenaline-induced vasoconstriction was lost in a Ca2+-free Krebs' solution, and the rate of loss of the response was accelerated by EGTA (2 mM). Noradrenaline-induced vasoconstriction and SDZ NVI085-induced vasoconstriction were concentration-dependently inhibited by verapamil and nifedipine. These agents were, however, more effective against KCl-induced responses. Cyclopiazonic acid, an intracellular Ca2+ depletor, concentration-dependently inhibited noradrenaline-induced responses and abolished the response in Ca2+-free Krebs' solution. GF 109203X and polymyxin B, inhibitors of protein kinase C (PKC), had no significant effect on noradrenaline-induced responses. Tyrosine kinase inhibitors, genistein and erbstatin, inhibited noradrenaline-induced vasoconstriction in theperfused rabbit ovarian vascular bed. The results would suggest that both extracellular Ca2+ and intracellular Ca2+ participate in noradrenaline-induced vasoconstrictor responses in the perfused rabbit ovarian vascular bed. The results would also suggest that tyrosine kinase and not protein kinase C activation has a role in such effects. (C) 1999 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:24:47