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Titolo:
Dynamics of translation on the ribosome: molecular mechanics of translocation
Autore:
Rodnina, MV; Savelsbergh, A; Wintermeyer, W;
Indirizzi:
Univ Witten Herdecke, Inst Mol Biol, D-58448 Witten, Germany Univ Witten Herdecke Witten Germany D-58448 iol, D-58448 Witten, Germany
Titolo Testata:
FEMS MICROBIOLOGY REVIEWS
fascicolo: 3, volume: 23, anno: 1999,
pagine: 317 - 333
SICI:
0168-6445(199906)23:3<317:DOTOTR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELONGATION-FACTOR-G; ESCHERICHIA-COLI RIBOSOME; ALLOSTERIC 3-SITE MODEL; FACTOR EF-G; FLUORESCENCE ENERGY-TRANSFER; DIRECTED CROSS-LINKING; TRANSFER-RNA; CRYSTAL-STRUCTURE; MESSENGER-RNA; P-SITE;
Keywords:
protein synthesis; tRNA; rRNA; elongation factor; GTPase; motor protein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Wintermeyer, W Univ Witten Herdecke, Inst Mol Biol, D-58448 Witten, Germany Univ Witten Herdecke Witten Germany D-58448 tten, Germany
Citazione:
M.V. Rodnina et al., "Dynamics of translation on the ribosome: molecular mechanics of translocation", FEMS MIC R, 23(3), 1999, pp. 317-333

Abstract

The translocation step of protein elongation entails a large-scale rearrangement of the tRNA-mRNA-ribosome complex. Recent years have seen major advances in unraveling the mechanism of the process on the molecular level. A number of intermediate states have been defined and, in part, characterized structurally. The article reviews the recent evidence that suggests a dynamic role of the ribosome and its ligands during translocation. The focus is on dynamic aspects of tRNA movement and on the role of elongation factor G and GTP hydrolysis in translocation catalysis. The significance of structural changes of the ribosome induced by elongation factor G as well the role of ribosomal RNA are addressed. A functional model of elongation factor G as a motor protein driven by GTP hydrolysis is discussed. (C) 1999 Publishedby Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:27:46