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Titolo:
Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons
Autore:
Stumm, G; Schlegel, J; Schafer, T; Wurz, C; Mennel, HD; Krieg, JC; Vedder, H;
Indirizzi:
Univ Marburg, Dept Neuropathol, Marburg, Germany Univ Marburg Marburg Germany arburg, Dept Neuropathol, Marburg, Germany Univ Marburg, Inst Forens Med, Marburg, Germany Univ Marburg Marburg Germany Marburg, Inst Forens Med, Marburg, Germany Univ Marburg, Dept Psychiat, Marburg, Germany Univ Marburg Marburg Germany v Marburg, Dept Psychiat, Marburg, Germany
Titolo Testata:
FASEB JOURNAL
fascicolo: 9, volume: 13, anno: 1999,
pagine: 1065 - 1072
SICI:
0892-6638(199906)13:9<1065:AIAARO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISMUTASE TRANSGENIC MICE; MDMA ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; METHAMPHETAMINE; CELLS; ABUSE; BRAIN; TRANSCRIPTION; DEATH; JUN;
Keywords:
drug abuse; neurotoxicity; bcl gene family;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stumm, G UnivermanyMarburg, Dept Psychiat, Rudolf-Bultmann Str 8, D-35039 Marburg, G Univ Hosp Marburg Rudolf-Bultmann Str 8 Marburg Germany D-35039
Citazione:
G. Stumm et al., "Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons", FASEB J, 13(9), 1999, pp. 1065-1072

Abstract

Amphetamine analogs have emerged as popular recreational drugs of abuse. The number of reports of these substances producing severe acute toxicity and death is increasing, In 'Ecstasy'-associated deaths, focal necrosis in the liver and individual myocytic necrosis has been reported. Furthermore, serotonergic and dopaminergic neuronal cell damage has been observed in experimental amphetamine intoxication in laboratory animals, Here we demonstratethat subchronic exposure to D-amphetamine, methamphetamine, methylenedioxyamphetamine, and methylenedioxymethamphetamine ('Ecstasy') results in significant neurotoxicity in rat neocortical neurons in vitro, This neuronal cell death is accompanied by endonucleosomal DNA cleavage and differential expression of anti- and proapoptotic bcl-x(L/S) splice variants. In addition, we observed pronounced induction of cell stress-associated transcription factor c-jun and translation initiation inhibitor p97 after amphetamine treatment. These data support that the neurotoxic effects of different amphetamines are extended to rat neocortical neurons and that apoptotic pathways areinvolved in amphetamine-induced neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:43:51