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Titolo:
The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia
Autore:
Wei, J; Hemmings, GP;
Indirizzi:
Schizophrenisnedd,c Great Britain, Inst Biol Psychiat, Bangor LL57 2AG, Gwy Schizophrenis Assoc Great Britain Bangor Gwynedd Wales LL57 2AG 2AG, Gwy
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 2, volume: 14, anno: 1999,
pagine: 67 - 70
SICI:
0924-9338(199904)14:2<67:TCRGPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ; DOPAMINE; VARIANT; CORTEX;
Keywords:
auditory hallucination; cholecystokinin (CCK) receptor; gene; polymerase chain reaction (PCR); restriction fragment length polymorphisms (RFLPs); schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wei, J Schizophrenis Assoc Great Britain, Inst Biol Psychiat, The Crescent, Bangor Schizophrenis Assoc Great Britain The Crescent Bangor Gwynedd Wales LL57 2AG
Citazione:
J. Wei e G.P. Hemmings, "The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia", EUR PSYCHIA, 14(2), 1999, pp. 67-70

Abstract

In this study, a Pstl polymorphic site with two individual alleles, namelyA1 and A2, was identified within the boundary between intron 1 and exon 2 of the cholecystokinin (CCK) type A receptor gene. The Pstl polymorphic site was used as a genetic marker to study its association with psychotic symptoms in schizophrenia. A significant difference in allelic frequency was found between schizophrenic patients with and without auditory hallucinations(chi(2) = 6.26, df = 1, P = 0.012), and the odds ratio for the allelic association was 2.21 (95% Cl 1.18-4.15) with an attributable fraction of 0.1. The frequency of A1-A1 and A1-A2 genotypes showed a significant excess in schizophrenic patients with auditory hallucinations as compared to those without such symptoms (chi(2) = 5.45, df = 1, P = 0.02), and the adds ratio for the genotypic association was 2.27 (95% Cl 1.13-4.57) with an attributable fraction of 0.177. The haplotype-based haplotype relative risk (HHRR) test revealed a significant difference between transmitted and non-transmittedalleles in nuclear families of schizophrenic patients with auditory hallucinations (chi(2) = 4.54, df = 1; P = 0.033) but not in those of schizophrenic patients without them, The present study suggests that the CCK-A receptor gene may be associated with auditory hallucinations in schizophrenia. (C)1999 Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 00:37:11