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Titolo:
Effect of the synthetic glucocorticoid, deflazacort, on body growth, pulsatile secretion of GH and thymolysis in the rat
Autore:
Latta, K; Krieg, RJ; Hisano, S; Veldhuis, JD; Chan, JCM;
Indirizzi:
Med Coll Virginia, Dept Pediat, Richmond, VA USA Med Coll Virginia Richmond VA USA irginia, Dept Pediat, Richmond, VA USA Med Coll Virginia, Dept Anat, Richmond, VA USA Med Coll Virginia RichmondVA USA Virginia, Dept Anat, Richmond, VA USA Univ Virginia, Dept Internal Med, Div Endocrinol, Charlottesville, VA USA Univ Virginia Charlottesville VA USA Endocrinol, Charlottesville, VA USA
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5, volume: 140, anno: 1999,
pagine: 441 - 446
SICI:
0804-4643(199905)140:5<441:EOTSGD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE MESSENGER-RNA; CATCH-UP GROWTH; RENAL-TRANSPLANTATION; GENE-EXPRESSION; PITUITARY CELLS; LINEAR GROWTH; DEXAMETHASONE; THERAPY; FAILURE; DECONVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Latta, K MHH, Kinderklin, Carl Neuberg Str 1, D-30625 Hannover, Germany MHH Carl Neuberg Str 1 Hannover Germany D-30625 annover, Germany
Citazione:
K. Latta et al., "Effect of the synthetic glucocorticoid, deflazacort, on body growth, pulsatile secretion of GH and thymolysis in the rat", EUR J ENDOC, 140(5), 1999, pp. 441-446

Abstract

Design: Deflazacort (DFZ) is a relatively new,glucocorticoid that has beenreported to exhibit fewer side-effects than other commonly used corticosteroids. The present study was designed to test the effects of DFZ on thymus gland involution (thymolysis), as compared with body growth and the secretory pattern of GH in the rat. Beginning at 38 days of age, male animals weretreated for 8 consecutive days by s.c. injection of DFZ (0.15 mg/day), cortisone (CORT) (5 mg/day) or vehicle (control, CTRL). Results: Both glucocorticoids had a similar thymolytic effect and caused growth failure. but the growth rate for the DFZ group was significantly higher than that of the CORT group. On day 46, pulsatile GH secretion was quantitated by blood sampling via an indwelling catheter at 10 min intervals for6 h. GK was assayed by RIA and analyzed by multiparameter deconvolution. CORT caused an increase in pulse frequency (5.8 +/- 0.4 (S.E.M.)) in comparison to DFZ (4.4 +/- 0.4) and CTRL (3.8 +/- 0.3). Both glucocorticoids significantly shortened the interval between secretory bursts. In CTRL, animals the interval between bursts was 69.3 +/- 4.5 min. In DFZ animals this was reduced to 58.5 +/- 7.1 min, and in CORT rats it was further reduced to 47.0+/- 2.6 min. The mass of GH secreted per burst was reduced in CORT animals(52% of CTRL), while DFZ did not alter this parameter. A similar trend wasobserved for total GH production, with CORT causing a reduction and DFZ not affecting the secretion. Conclusion: Rats treated with glucocorticoid show a profound thymolytic effect, as well as important changes in growth. While CORT suppresses GH secretion and alters its pulsatile mode of release, DFZ causes a less significant alteration in the pattern of GH secretion and does not negatively affectthe overall amount of GH secreted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:20:21