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Titolo: Amniotic fluid concentrations of dimeric inhibins, activin A and follistatin in pregnancy
Autore: Muttukrishna, S; Chamberlain, P; Evans, LW; Asselin, J; Groome, NP; Ledger, WL;
- Indirizzi:
- Johnndadcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, Engla John Radcliffe Hosp Oxford England OX3 9DU naecol, Oxford OX3 9DU, Engla Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England Oxford Brookes Univ Oxford England OX3 0BP Sci, Oxford OX3 0BP, England
- Titolo Testata:
- EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5,
volume: 140,
anno: 1999,
pagine: 420 - 424
- SICI:
- 0804-4643(199905)140:5<420:AFCODI>2.0.ZU;2-T
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HUMAN MENSTRUAL-CYCLE; 2-SITE ENZYME-IMMUNOASSAY; SERUM CONCENTRATIONS; FOLLICULAR-FLUID; MATERNAL SERUM; HUMAN-PLACENTA; BETA-A; SUBUNITS; LOCALIZATION; VALIDATION;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 26
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Muttukrishna, S Johnndadcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, Engla John Radcliffe Hosp Oxford England OX3 9DU X3 9DU, Engla
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- Citazione:
- S. Muttukrishna et al., "Amniotic fluid concentrations of dimeric inhibins, activin A and follistatin in pregnancy", EUR J ENDOC, 140(5), 1999, pp. 420-424
Abstract
Objective: The fete-placental unit is the major source of circulating concentrations of inhibin A and activin A in human pregnancy The aim of this study was to measure the amniotic fluid concentrations of inhibin A, inhibin B, activin A and follistatin in pregnancies bearing male and female fetuses. Design and Method: Amniotic fluid samples collected by amniocentesis were stored at -20 degrees C. Dimeric inhibins, 'total' activin A and 'total' follistatin were measured using specific two-site enzyme immunoassays. Samples were assayed blindly and the information on fetal sex was obtained from the cytogenetics laboratory. Results: Data show that: amniotic fluid concentrations of inhibin A, inhibin B and activin A gradually increase with gestation whilst concentrations of follistatin are similar between weeks 15 and 20 of pregnancy. Mean amniotic fluid levels of inhibin A and inhibin B at 16 and 17 weeks gestation and mean activin A levels at 15 and 16 weeks gestation are considerably lowerin pregnancies with male (n = 24) compared with female (n = 28) fetuses. Levels of follistatin are not different in the male and female fetal pregnancies at any studied gestation. Conclusions: The results indicate that amniotic fluid contains high concentrations of inhibins (A and B), activin A and follistatin in early pregnancy suggesting that these hormones are produced by the fetal membranes and may be involved in the development of the fetus.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:02:22