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Titolo:
Amniotic fluid concentrations of dimeric inhibins, activin A and follistatin in pregnancy
Autore:
Muttukrishna, S; Chamberlain, P; Evans, LW; Asselin, J; Groome, NP; Ledger, WL;
Indirizzi:
Johnndadcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, Engla John Radcliffe Hosp Oxford England OX3 9DU naecol, Oxford OX3 9DU, Engla Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England Oxford Brookes Univ Oxford England OX3 0BP Sci, Oxford OX3 0BP, England
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 5, volume: 140, anno: 1999,
pagine: 420 - 424
SICI:
0804-4643(199905)140:5<420:AFCODI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; 2-SITE ENZYME-IMMUNOASSAY; SERUM CONCENTRATIONS; FOLLICULAR-FLUID; MATERNAL SERUM; HUMAN-PLACENTA; BETA-A; SUBUNITS; LOCALIZATION; VALIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Muttukrishna, S Johnndadcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, Engla John Radcliffe Hosp Oxford England OX3 9DU X3 9DU, Engla
Citazione:
S. Muttukrishna et al., "Amniotic fluid concentrations of dimeric inhibins, activin A and follistatin in pregnancy", EUR J ENDOC, 140(5), 1999, pp. 420-424

Abstract

Objective: The fete-placental unit is the major source of circulating concentrations of inhibin A and activin A in human pregnancy The aim of this study was to measure the amniotic fluid concentrations of inhibin A, inhibin B, activin A and follistatin in pregnancies bearing male and female fetuses. Design and Method: Amniotic fluid samples collected by amniocentesis were stored at -20 degrees C. Dimeric inhibins, 'total' activin A and 'total' follistatin were measured using specific two-site enzyme immunoassays. Samples were assayed blindly and the information on fetal sex was obtained from the cytogenetics laboratory. Results: Data show that: amniotic fluid concentrations of inhibin A, inhibin B and activin A gradually increase with gestation whilst concentrations of follistatin are similar between weeks 15 and 20 of pregnancy. Mean amniotic fluid levels of inhibin A and inhibin B at 16 and 17 weeks gestation and mean activin A levels at 15 and 16 weeks gestation are considerably lowerin pregnancies with male (n = 24) compared with female (n = 28) fetuses. Levels of follistatin are not different in the male and female fetal pregnancies at any studied gestation. Conclusions: The results indicate that amniotic fluid contains high concentrations of inhibins (A and B), activin A and follistatin in early pregnancy suggesting that these hormones are produced by the fetal membranes and may be involved in the development of the fetus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:02:22