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Titolo:
Myocardial ischaemia in children with isolated ventricular non-compaction
Autore:
Junga, G; Kneifel, S; Von Smekal, A; Steinert, H; Bauersfeld, U;
Indirizzi:
Univ Zurich, Childrens Hosp, Div Cardiol, CH-8032 Zurich, Switzerland UnivZurich Zurich Switzerland CH-8032 diol, CH-8032 Zurich, Switzerland Univ Zurich Hosp, Dept Radiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Clin Nucl Med, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 12, volume: 20, anno: 1999,
pagine: 910 - 916
SICI:
0195-668X(199906)20:12<910:MIICWI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ISOLATED NONCOMPACTION; HYPERTROPHIC CARDIOMYOPATHY; HEART-DISEASE; N-13 AMMONIA; FLOW RESERVE; BLOOD-FLOW; ECHOCARDIOGRAPHY; QUANTIFICATION; PERSISTENCE;
Keywords:
non-compaction; ischaemia; cardiomyopathy; ventricles; imaging; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bauersfeld, U UnivSwitzerlandildrens Hosp, Div Cardiol, Steinwiesstr 75, CH-8032 Zurich, Univ Zurich Steinwiesstr 75 Zurich Switzerland CH-8032 ich,
Citazione:
G. Junga et al., "Myocardial ischaemia in children with isolated ventricular non-compaction", EUR HEART J, 20(12), 1999, pp. 910-916

Abstract

Aims Isolated ventricular non-compaction is a rare congenital cardiomyopathy with a high morbidity and mortality due to malignant arrhythmias and pump failure. Areas affected by non-compaction are characterized by increased trabecularization and deep inter-trabecular spaces. We hypothesized perfusion defects in these areas and performed positron emission tomography to evaluate the myocardial perfusion in non-compacted areas. Methods and Results Five children (age 10-14 years) with isolated ventricular non-compaction underwent positron emission tomography using N-13-ammonia as flow marker and intravenous dipyridamole for stress testing. Myocardial blood flow was quantified using the positron emission tomography time-activity curves in noncompacted areas and normal myocardium. which were diagnosed by echocardiography. magnetic resonance imaging, and angiography. Coronary angiography, performed in two children with extensive forms of left ventricular non-compaction, demonstrated normal coronary arteries. Myocardial blood flow measurements at rest and after dipyridamole application demonstrated 16-33% and 32-57% perfusion impairment, respectively,in non-compacted areas compared to normal myocardium. Areas of restricted myocardial perfusion corresponded well to the noncompacted areas, defined echographically andby magnetic resonance imaging. Conclusion Positron emission tomography demonstrates restricted myocardialperfusion and decreased flow reserve in areas of ventricular non-compaction in children. The myocardial perfusion defects in non-compacted areas may be the cause of myocardial damage and possibly form the basis of arrhythmias and pump failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:25:04