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Titolo:
CCR7 ligands, SLC/6Ckine/Exodus2/TCA4 and CK beta-11/MIP-3 beta/ELC, are chemoattractants for CD56(+)CD16(-) NK cells and late stage lymphoid progenitors
Autore:
Kim, CH; Pelus, LM; Appelbaum, E; Johanson, K; Anzai, N; Broxmeyer, HE;
Indirizzi:
Indiana Univ, Sch Med, Dept Microbiol Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ol Ctr, Indianapolis, IN 46202 USA Walther Canc Inst, Indianapolis, IN 46208 USA Walther Canc Inst Indianapolis IN USA 46208 t, Indianapolis, IN 46208 USA SmithKline Beecham Pharmaceut, Dept Mol Virol, Collegeville, PA 19426 USA SmithKline Beecham Pharmaceut Collegeville PA USA 19426 lle, PA 19426 USA SmithKline Beecham Pharmaceut, Dept Host Def, Collegeville, PA 19426 USA SmithKline Beecham Pharmaceut Collegeville PA USA 19426 lle, PA 19426 USA SmithKline Beecham Pharmaceut, Mol Genet, King Of Prussia, PA 19406 USA SmithKline Beecham Pharmaceut King Of Prussia PA USA 19406 , PA 19406 USA SmithKline Beecham Pharmaceut, Prot Biochem, King Of Prussia, PA 19406 USASmithKline Beecham Pharmaceut King Of Prussia PA USA 19406 , PA 19406 USA
Titolo Testata:
CELLULAR IMMUNOLOGY
fascicolo: 2, volume: 193, anno: 1999,
pagine: 226 - 235
SICI:
0008-8749(19990501)193:2<226:CLSACB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; PROTEIN-3-BETA EBI1-LIGAND CHEMOKINE; HETEROTRIMERIC G-PROTEINS; SIGNAL SEQUENCE TRAP; B-CELL; T-CELL; MOLECULAR-CLONING; DENDRITIC CELLS; BETA-CHEMOKINE; LYMPHOCYTES;
Keywords:
NK cells; progenitors; SLC/6Ckine/exodus2/TCA4; CK beta-11/MIP-3 beta/ELC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, CH Indiana Univ, Sch Med, Dept Microbiol Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Indianapolis, IN 46202 USA
Citazione:
C.H. Kim et al., "CCR7 ligands, SLC/6Ckine/Exodus2/TCA4 and CK beta-11/MIP-3 beta/ELC, are chemoattractants for CD56(+)CD16(-) NK cells and late stage lymphoid progenitors", CELL IMMUN, 193(2), 1999, pp. 226-235

Abstract

Two human CC chemokines, SLC/6Ckine/Exodus2/TCA4 and CK beta-11/MIP-3 beta/ELC, are previously reported as efficacious chemoattractants for T- and B-cells and dendritic cells. SLC and CK beta-11 share only 32% amino acid identity, but are Ligands for the same chemokine receptor, CCR7. In this study, we examined chemotactic activity of SLC and CK beta-11 for NK cells and lymphoid progenitors in bone marrow and thymus. It was found that these two CCR7 ligands are chemoattractants for neonatal cord blood and adult peripheral blood NK cells and cell lines. SLC and CK beta-11 preferentially attract the CD56(+)CD16(-) NK cell subset over CD56(+)CD16(+) NK cells. SLC and CK beta-11 also demonstrate selective chemotactic activity on late stage CD34(-)CD19(+)IgM(-) B-cell progenitors and CD4(+) and CD8(+) single-positive thymocytes, but not early stage progenitors. It was noted that SLC is an efficient desensitizer of CK beta-11-dependent MR cell chemotaxis, while CK beta-11 is a weak desensitizer of SLC-dependent chemotaxis. Taken together, these results suggest that SLC and CK beta-11 have the potential to controltrafficking of NK cell subsets and late stage lymphoid progenitors in bonemarrow and thymus. (C) 1999 Academic Press.

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Documento generato il 01/04/20 alle ore 09:45:58