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Titolo:
Non-ventilatory treatment of acute hypoxic respiratory failure
Autore:
Young, JD;
Indirizzi:
Radcliffe Infirm, Nuffield Dept Anaesthet, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE aesthet, Oxford OX2 6HE, England
Titolo Testata:
BRITISH MEDICAL BULLETIN
fascicolo: 1, volume: 55, anno: 1999,
pagine: 165 - 180
SICI:
0007-1420(1999)55:1<165:NTOAHR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED NITRIC-OXIDE; EXTRACORPOREAL MEMBRANE-OXYGENATION; OBSTRUCTIVE PULMONARY-DISEASE; CRITICALLY ILL PATIENTS; GAS-EXCHANGE RESPONSES; DISTRESS-SYNDROME; PRONE POSITION; DOUBLE-BLIND; AEROSOLIZED PROSTACYCLIN; ALMITRINE BISMESYLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Young, JD Radcliffeglandrm, Nuffield Dept Anaesthet, Woodstock Rd, Oxford OX2 6HE, En Radcliffe Infirm Woodstock Rd Oxford England OX2 6HE X2 6HE, En
Citazione:
J.D. Young, "Non-ventilatory treatment of acute hypoxic respiratory failure", BR MED B, 55(1), 1999, pp. 165-180

Abstract

Severe acute hypoxic respiratory failure is uncommon but often fatal. Standard treatment involves high inspired oxygen concentrations, mechanical ventilation and positive end-expiratory pressure. Many other interventions have been used in parallel with conventional treatment or as rescue therapy when it fails, including extracorporeal gas exchange, prone positioning, inhaled vasodilators, exogenous surfactants and drugs which modify the inflammatory process. Nearly all these treatments improve arterial oxygenation or markers of lung injury. However, the relationship between oxygenation and survival in acute hypoxaemic respiratory failure is not established, so improved oxygenation cannot be used as a surrogate for survival. Randomised controlled trials are, therefore, needed to assess the effects of these treatments on mortality In such trials, extracorporeal oxygenation and extracorporeal carbon dioxide elimination, surfactant, early methylprednisolone, and prostaglandin E-1, offer no survival advantage over conventional therapy. Prophylactic ketoconazole and pentoxifylline appear to improve mortality in small studies in surgical and oncology patients respectively, and methylprednisolone improves mortality and morbidity in unresolving disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:32:37