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Titolo:
Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter
Autore:
Dickey, CC; McCarley, RW; Voglmaier, MM; Niznikiewicz, MA; Seidman, LJ; Hirayasu, Y; Fischer, I; Teh, EK; Van Rhoads, R; Jakab, M; Kikinis, R; Jolesz, FA; Shenton, ME;
Indirizzi:
Harvard Univ, Sch Med, Dept Psychiat, Brockto VAMC, Brockton, MA 02401 USAHarvard Univ Brockton MA USA 02401 , Brockto VAMC, Brockton, MA 02401 USA Harvard Univ, Sch Med, Dept Radiol, Brigham & Womens Hosp, Boston, MA USA Harvard Univ Boston MA USA Radiol, Brigham & Womens Hosp, Boston, MA USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 11, volume: 45, anno: 1999,
pagine: 1393 - 1402
SICI:
0006-3223(19990601)45:11<1393:SPDAMA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; STRUCTURAL ABNORMALITIES; AUDITORY HALLUCINATIONS; BRAIN ABNORMALITIES; ERP ABNORMALITIES; THOUGHT-DISORDER; GYRUS VOLUME; ASYMMETRY; MORPHOLOGY; IMPAIRMENT;
Keywords:
schizotypal personality disorder; schizophrenia; magnetic resonance imaging; temporal lobe; superior temporal gyrus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: McCarley, RW Harvardntniv, Sch Med, Dept Psychiat, Brockto VAMC, Psychiat 116A,940 Belmo Harvard Univ Psychiat 116A,940 Belmont St Brockton MA USA 02401
Citazione:
C.C. Dickey et al., "Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter", BIOL PSYCHI, 45(11), 1999, pp. 1393-1402

Abstract

Background: Structural MRI data indicate schizophrenics have reduced left-sided temporal lobe gray matter volumes, especially in the superior temporal gyrus (STG) and medial temporal lobe. Our data further suggest a specificity to schizophrenia spectrum disorders of STG volume reduction, Interpretation of research studies involving schizophrenics may be complicated by theeffects of exposure to neuroleptics and chronic illness. Sharing the same genetic diathesis of schizophrenics, subjects with schizotypal personality disorder (SPD) offer a unique opportunity to evaluate commonalities betweenschizophrenia and SPD, particularly as SPD subjects are characterized by cognitive and perceptual distortions, an inability to tolerate close friendships, and odd behavior but they are not psychotic and so have generally notbeen prescribed neuroleptics nor hospitalized. Evaluation of brain structure in SPD may thus offer insight into the "endophenotype" common to both disorders. In addition, differences between groups may suggest which are the brain structures of schizophrenics that contribute to the development of psychosis. Methods: To test the hypothesis of whether SPD subjects might show similarSTG abnormalities, STG and medial temporal lobe regions of interest (ROI) were manually drawn on high resolution coronal MRI 1.5 mm thick slices. Images were derived from 16 right-handed male SPD subjects, without regard to family history, and 14 healthy, right-handed comparison males who did nor differ from the SPD group on parental socio-economic status, age, or verbal IQ. Results: As predicted, SPD subjects showed a reduction in left STG gray matter volume compared with age and gender matched comparison subjects. SPD subjects also showed reduced parahippocampal left/right asymmetry and a highdegree of disordered thinking. Comparisons with chronic schizophrenics previously studied by us showed the SPD group had a similarity of left STG gray matter volume reduction, but fewer medial temporal lobe abnormalities. Conclusions: These abnormalities strengthen the hypothesis of a temporal lobeabnormality in SPD, and the similarity of STG findings in schizophrenia and SPD suggest that STG abnormalities may be part of the spectrum "endophenotype. " It is also possible that presence of medial temporal lobe abnormalities may help to differentiate who will develop schizophrenia and who will develop the less severe schizophrenia spectrum disorder, SPD. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 18/01/20 alle ore 02:00:05