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Titolo:
Genetic analysis of B cell antigen receptor signaling
Autore:
Kurosaki, T;
Indirizzi:
KansaiJapanUniv, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506,Kansai Med Univ Moriguchi Osaka Japan 5708506 , Moriguchi, Osaka 5708506,
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 17, anno: 1999,
pagine: 555 - 592
SICI:
0732-0582(1999)17:<555:GAOBCA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; X-LINKED AGAMMAGLOBULINEMIA; LYN-DEFICIENT MICE; GLYCOGEN-SYNTHASE KINASE-3; VAV PROTOONCOGENE PRODUCT; ALDRICH-SYNDROME PROTEIN; PHOSPHORYLATED IG-ALPHA; SRC FAMILY KINASES; T-CELL; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
signal transduction; BCR; Syk; Btk; BLNK; PLC-gamma 2; PI-3K; calcium signal;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Kurosaki, T Kansaichi, Univ, Inst Liver Res, Dept Mol Genet, 10-15 Rumizono Cho, Morigu Kansai Med Univ 10-15 Rumizono Cho Moriguchi Osaka Japan 5708506
Citazione:
T. Kurosaki, "Genetic analysis of B cell antigen receptor signaling", ANN R IMMUN, 17, 1999, pp. 555-592

Abstract

In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments incell lines and mice have revealed distinct functions for the intracellularprotein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:44:49