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Titolo:
Comparative efficacy and safety of ondansetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting: A meta-analysis
Autore:
Domino, KB; Anderson, EA; Polissar, NL; Posner, KL;
Indirizzi:
Univ Washington, Sch Med, Dept Anesthesiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Anesthesiol, Seattle, WA 98195 USA Mt Whisper Light Stat Consulting, Seattle, WA USA Mt Whisper Light Stat Consulting Seattle WA USA sulting, Seattle, WA USA
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 6, volume: 88, anno: 1999,
pagine: 1370 - 1379
SICI:
0003-2999(199906)88:6<1370:CEASOO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC ANTIEMETIC THERAPY; PATIENT-CONTROLLED ANALGESIA; MAJOR GYNECOLOGICAL SURGERY; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; STRABISMUS SURGERY; FEMALE-PATIENTS; PEDIATRIC-PATIENTS; DOSE-RESPONSE; LAPAROSCOPIC CHOLECYSTECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Domino, KB UnivSAashington, Sch Med, Dept Anesthesiol, Box 356540, Seattle, WA 98195 U Univ Washington Box 356540 Seattle WA USA 98195 tle, WA 98195 U
Citazione:
K.B. Domino et al., "Comparative efficacy and safety of ondansetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting: A meta-analysis", ANESTH ANAL, 88(6), 1999, pp. 1370-1379

Abstract

Postoperative nausea and vomiting are important causes of morbidity after anesthesia and surgery. We performed a meta-analysis of published, randomized, controlled trials to determine the relative efficacy and safety of ondansetron, droperidol, and metoclopramide for the prevention of postoperativenausea and vomiting. We performed a Literature search of English references using both the MEDLINE database and a manual search. Double-blinded, randomized, controlled trials comparing the efficiency of the prophylactic administration of ondansetron, droperidol, and/or metoclopramide therapy duringgeneral anesthesia were included. A total of 58 studies were identified, of which 4 were excluded for methodological concerns. For each comparison ofdrugs, a pooled odds ratio (OR) with a 95% CT was calculated using a random effects model. Ondansetron (pooled OR 0.43, 95% CI0.31, 0.61; P < 0.001) and droperidol (pooled OR 0.68, 95% CI0.54, 0.85; P < 0.001) were more effective than metoclopramide in preventing vomiting. Ondansetron was more effective than droperidol in preventing vomiting in children (pooled OR 0.49; P= 0.004), but they were equally effective in adults (pooled OR 0.87; P = 0.45). The overall risk of adverse effects was not different among drug combinations. We conclude that ondansetron and droperidol are more effective than metoclopramide in reducing postoperative vomiting. Implications: We performed a systematic review of published, randomized, controlled trials to determine the relative efficacy and safety of ondansetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting. Ondansetron and droperidol were more effective than metoclopramide in reducing postoperative vomiting. The overall risk of adverse effects did not differ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:54:21