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Titolo:
Immunohistochemical study of steroidogenic enzymes in the ovary and placenta during pregnancy in the dog
Autore:
Nishiyama, T; Tsumagari, S; Ito, M; Kimura, J; Watanabe, G; Taya, K; Takeishi, M;
Indirizzi:
NihonFujisawa,ll Bioresource Sci, Dept Vet Anat, Lab Vet Obstet & Gynecol,Nihon Univ Fujisawa Kanagawa Japan 2528510 nat, Lab Vet Obstet & Gynecol,
Titolo Testata:
Anatomia, histologia, embryologia
fascicolo: 2, volume: 28, anno: 1999,
pagine: 125 - 129
SICI:
0340-2096(199905)28:2<125:ISOSEI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; MENSTRUAL-CYCLE; CORPUS-LUTEUM; PARTURITION; ESTROGEN; PROGESTERONE; RAT; 17-ALPHA-HYDROXYLASE; TESTOSTERONE; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nishiyama, T NihonFujisawa,ll Bioresource Sci, Dept Vet Anat, Lab Vet Obstet & Gynecol, Nihon Univ Fujisawa Kanagawa Japan 2528510 Obstet & Gynecol,
Citazione:
T. Nishiyama et al., "Immunohistochemical study of steroidogenic enzymes in the ovary and placenta during pregnancy in the dog", ANAT HISTOL, 28(2), 1999, pp. 125-129

Abstract

Using the immunohistochemical technique, we attempted to identify the source of secretion of steroid hormones between the mid- and late-terms of gestation in dogs by investigating steroid converting enzymes such as cholesterol side-chain cleavage enzyme (SCC), 3 beta-hydroxysteroid dehydrogenase/isomerase (3 P-HSD), 17 alpha-hydroxylase/C17, 20lyase (c17), and aromatase in the ovaries and placenta. Aromatase positive cells were slightly confirmed in luteal cells in the midterm of gestation (day 40), whereas, in the late-stage (day 50 and 60), the number of aromatase positive cells had increased. However, the oestrogen precursor (c-17 positive cells), could barely beidentified in the marginal regions of the corpora lutea (CL) and completely disappeared in the late-stage of gestation. The androgen precursors, convertase SCC and 3 beta-HSD, were confirmed in all regions of the CL during the mid-stage of gestation (day 40), showing particularly strong cell reactions in the marginal region of the CL. Yet, these positive reactions of SCC and 3 beta-HSD in the marginal region of the CL disappeared in the late-stage of gestation. Moreover, it was discovered that the number of SCC and 3 beta-HSD positive cells had decreased in all regions of the CL. None of the enzymes were detected in the placenta. The above results indicated that thesource of oestrogen secretion in pregnant dogs is considered to be the CL,and that, compared with the mid-stage of gestation, there was an increasednumber of oestrogen synthesizing cells within the CL in the late-stage. However, the biosynthetic site of oestrogen precursors from the luteal cells during the late-stage of gestation is still unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:19:58