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Titolo:
Hepatocellular carcinoma in Egyptians with and without a history of hepatitis B virus infection: Association with hepatitis C virus (HCV) infection but not with HCV RNA level
Autore:
Yates, SC; Hafez, M; Beld, M; Lukashov, VV; Hassan, Z; Carboni, G; Khaled, H; McMorrow, M; Attia, M; Goudsmit, J;
Indirizzi:
UnivNetherlands Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam,Univ Amsterdam Amsterdam Netherlands NL-1105 AZ l, NL-1105 AZ Amsterdam, Cairo Univ, Natl Canc Inst, Dept Virol & Immunol, Cairo, Egypt Cairo UnivCairo Egypt tl Canc Inst, Dept Virol & Immunol, Cairo, Egypt Cairo Univ, Natl Canc Inst, Dept Med Oncol, Cairo, Egypt Cairo Univ Cairo Egypt iv, Natl Canc Inst, Dept Med Oncol, Cairo, Egypt Univ Cagliari, Dept Hyg & Publ Hlth, Cagliari, Italy Univ Cagliari Cagliari Italy ari, Dept Hyg & Publ Hlth, Cagliari, Italy Chiron Diagnost, Amsterdam, Netherlands Chiron Diagnost Amsterdam Netherlands Diagnost, Amsterdam, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 4, volume: 60, anno: 1999,
pagine: 714 - 720
SICI:
0002-9637(199904)60:4<714:HCIEWA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LIVER-DISEASE; BLOOD-DONORS; HIGH SEROPREVALENCE; NATURAL-HISTORY; HIGH PREVALENCE; BLADDER-CANCER; EPIDEMIOLOGY; RISK; SCHISTOSOMIASIS; GENOTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Yates, SC Univ1-155,rdam, Acad Med Ctr, Dept Human Retrovirol, Meibergdreef 15,Room L Univ Amsterdam Meibergdreef 15,Room L1-155 Amsterdam Netherlands NL-1105 AZ
Citazione:
S.C. Yates et al., "Hepatocellular carcinoma in Egyptians with and without a history of hepatitis B virus infection: Association with hepatitis C virus (HCV) infection but not with HCV RNA level", AM J TROP M, 60(4), 1999, pp. 714-720

Abstract

The aim of this study was to analyze the association of hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) in Egypt, using hepatitis B virus(HBV) and hepatitis E virus (HEV) as virus controls. In addition, the association of HCC with HCV RNA levels among persons seropositive for HCV was analyzed. We compared 131 patients with proven HCC, 247 with bladder cancer,and 466 healthy hospital employees. Age, sex, and place of residence were recorded to study confounding factors. Among the healthy controls, 16% wereseropositive for HCV, 21% for HBV, and 31% for HEV. When healthy controls were age-matched with HCC patients, the latter were significantly (P < 0.001) more often HCV seropositive (67%) than were the controls (30%). The seropositivity for HBV and HEV did not differ significantly in frequency between the two groups. The seropositivity for HCV was also significantly (P < 0.001) more often found in HCC patients (76%) than in BC patients (47%), withseroprevalences for HBV and HEV not differing significantly in these age-matched groups. In HBV-negative HCC and bladder cancer patients, seroprevalence for HCV was significantly (P = 0.002) higher in HCC patients (68%) thanin bladder cancer patients (36%). This difference was even more pronounced(P < 0.001) in HBV-positive WCC and bladder cancer patients (78% versus 52%, respectively). Of HCV-seropositive individuals, 49% were HCV RNA positive by branched DNA assay, and of these, 96% were infected by HCV genotype 4. No correlation between HCV RNA load and seropositivity of HBV or age or disease state was found. Infection with HCV and HCV-HBV double infection, butnot HBV or HEV infection alone, is strongly correlated with HCC in Egypt.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:03:30