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Titolo:
Evidence for an improvement in cognitive function following treatment of Schistosoma japonicum infection in Chinese primary schoolchildren
Autore:
Nokes, C; McGarvey, ST; Shiue, L; Wu, GL; Wu, HW; Bundy, DAP; Olds, GR;
Indirizzi:
Univ Oxford, Partnership Child Dev, Oxford OX1 3PS, England Univ Oxford Oxford England OX1 3PS ip Child Dev, Oxford OX1 3PS, England Brown Univ, Program Geog Med, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ram Geog Med, Providence, RI 02912 USA Nanjing Med Univ, Dept Parasitol, Nanjing 210029, Jiangsu, Peoples R ChinaNanjing Med Univ Nanjing Jiangsu Peoples R China 210029 , Peoples R China Case Western Reserve Univ, Metrohlth Med Ctr, Dept Med, Cleveland, OH 44109 Case Western Reserve Univ Cleveland OH USA 44109 Med, Cleveland, OH 44109
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 4, volume: 60, anno: 1999,
pagine: 556 - 565
SICI:
0002-9637(199904)60:4<556:EFAIIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITIONAL-STATUS; SCHOOL-CHILDREN; WORKING-MEMORY; INTESTINAL PARASITES; GROWTH; PERFORMANCE; AFRICA; ZAIRE; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Nokes, C Univ Oxford, Partnership Child Dev, S Parks Rd, Oxford OX1 3PS, England Univ Oxford S Parks Rd Oxford England OX1 3PS d OX1 3PS, England
Citazione:
C. Nokes et al., "Evidence for an improvement in cognitive function following treatment of Schistosoma japonicum infection in Chinese primary schoolchildren", AM J TROP M, 60(4), 1999, pp. 556-565

Abstract

A double-blind, placebo-controlled, treatment trial was conducted in Sichuan, China to investigate the unique and combined effects on the cognitive function (working memory) of children after treating geohelminth infections with albendazole and treating Schistosoma japonicum infection with praziquantel. One hundred eighty-one children 5-16 years of age participated. At baseline, the praziquantel and placebo groups were similar in all background characteristics. Three months after praziquantel treatment, there was a significant reduction in the prevalence and intensity of S. japonicum infection. There were significant age group by praziquantel treatment interaction effects in three of the five cognitive tests, Fluency, Picture Search, and Free Recall, with effects being strongest in the youngest children (5-7 years old). Exploratory analysis within the youngest children showed a significant positive main effect of treatment on Fluency (P < 0.001), after controlling for sex, anthropometric, and parasitic and iron status. There was alsoa treatment by height-for-age interaction (P = 0.03) and a treatment by iron status interaction (P = 0.024) on Fluency. There was a treatment by S. japonicum intensity interaction (P < 0.001) on Free Recall, but the main effect of treatment on Picture Search was not significant (P = 0.058). Youngerchildren and those who are physically the most vulnerable are likely to benefit the most from the treatment of S. japonicum infection in terms of improved performance on tests of working memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:38:20