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Titolo:
Cardiac sympathetic activity as measured by myocardial 123-I-metaiodobenzylguanidine uptake and heart rate variability in idiopathic dilated cardiomyopathy
Autore:
Lotze, U; Kober, A; Kaepplinger, S; Neubauer, S; Gottschild, D; Figulla, HR;
Indirizzi:
Univermany Dept Internal Med Cardiol Angiol Intens Care Med, D-6900 Jena, G Univ Jena Jena Germany D-6900 iol Angiol Intens Care Med, D-6900 Jena, G Univ Jena, Dept Nucl Med, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 Jena, Dept Nucl Med, D-6900 Jena, Germany
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 11, volume: 83, anno: 1999,
pagine: 1548 - 1551
SICI:
0002-9149(19990601)83:11<1548:CSAAMB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PACED CANINE MODEL; METAIODOBENZYLGUANIDINE SCINTIGRAPHY; PROGNOSTIC VALUE; FAILURE; INFARCTION; ACTIVATION; WASHOUT; DISEASE; SYSTEM; TONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lotze, U Klinikum Friedrich Schiller Univ, D-07740 Jena, Germany Klinikum Friedrich Schiller Univ Jena Germany D-07740 , Germany
Citazione:
U. Lotze et al., "Cardiac sympathetic activity as measured by myocardial 123-I-metaiodobenzylguanidine uptake and heart rate variability in idiopathic dilated cardiomyopathy", AM J CARD, 83(11), 1999, pp. 1548-1551

Abstract

In patients with idiopathic dilated cardiomyopathy (IDC) the increased sympathetic activity owing to chronic congestive heart failure leads to an imbalance of cardiac autonomic tone, as reflected by decreased heart rate variability (HRV). Iodine-123-metaiodobenzylguanidine (123-I-MIBG), which has the same affinity for sympathetic nerve endings as norepinephrine, can be used to assess the integrity and function of the cardiac sympathetic nervous system. The aim of the present study was to measure cardiac sympathetic activity by assessing 123-I-MIBG uptake compared with HRV in patients with IDC. In 12 patients with IDC and mild to moderate heart failure, myocardial MIBG uptake was calculated from the myocardial (M) to left ventricular cavity(C) voxel values density ratio and the 123-I activity in a blood sample asa reference (= M/C ratio) using a double radionuclide study with 123-I-MIBG and technetium-99m-MIBI. To investigate the relation between myocardial MIBG uptake and HRV in time domain, the linear regression between the M/C ratio, a new scintigraphic parameter, and the mean RR interval or the HRV triangular index, respectively, was determined. A significant correlation between the M/C ratio and mean RR interval (r = 0.52; p = 0.016) or M/C ratio and HRV triangular index (r 0.76; p = 0.003), respectively, was found. Thus,the significant correlation between the MIC ratio and HRV indicate that they are both suitable noninvasive methods for evaluating cardiac sympatheticactivity in patients with IDC and, furthermore, favor the view that there is evidence of a relation between HRV and the disorder of the cardiac presynaptic sympathetic nerve endings as demonstrated by a reduced MIC ratio. (C) 1999 by Excerpta Medica Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:36:25